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INSIGHT, A Comprehensive, Multidisciplinary Brain Training System (INSIGHT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02780739
Recruitment Status : Completed
First Posted : May 23, 2016
Last Update Posted : May 23, 2016
Sponsor:
Collaborators:
The City College of New York
Aptima, Inc.
Georgia Institute of Technology
Circinnus LLC
Autonomous University of Madrid, Spain
Information provided by (Responsible Party):
University of Illinois at Urbana-Champaign

Brief Summary:
Adaptive reasoning and problem-solving are critical skills that allow for accurate decisions to be made based on varying levels of information. In many situations these decisions must be made and communicated under stressful, time-sensitive conditions. In such contexts, an ability to apply inductive and deductive reasoning to complex, ambiguous, and/or novel problems is critical. The objective of the INSIGHT project is to establish a comprehensive and rigorous brain training protocol to significantly improve adaptive reasoning and problem solving. We will examine a variety of interventions (cognitive training, physical fitness training, physiological stimulation, , and combinations thereof) to assess their ability to improve adaptive reasoning and problem solving abilities. Multimodal interventions are hypothesized to act synergistically to significantly enhance fluid intelligence (Gf) and underlying brain structure and function.

Condition or disease Intervention/treatment Phase
Cognitive Ability, General Behavioral: Cognitive Training - 48 sessions Behavioral: Fitness Behavioral: Active Control Device: active tDCS Device: sham tDCS Behavioral: Cognitive Training - 20 sessions Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 521 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Official Title: An Integrative System for Enhancing Fluid Intelligence (Gf) Through Human Cognitive Activity, Fitness, High-definition Transcranial Direct-current Brain Stimulation (HD-tDCS), and Nutritional Intervention
Study Start Date : March 2014
Actual Primary Completion Date : November 2014
Actual Study Completion Date : November 2014

Arm Intervention/treatment
Experimental: Cognitive Training - 48 sessions
56 hours of video game training with Mind Frontiers adaptive cognitive training software (48 70-min sessions distributed over 16 weeks)
Behavioral: Cognitive Training - 48 sessions
Mind Frontiers cognitive training software (Aptima Inc.) is a Wild West-themed Android application played on Nexus 10 tablets. This intervention includes 20 70-min sessions (23.33 hrs) completed over 12 weeks: 1/wk weeks 5-8, 2/wk weeks 9-16. The 6 mini-games, played in random order for 10 min each session, are Ante Up (Tower of London, executive functioning); Irrigator (visuospatial reasoning); Pen 'Em Up (dual task switching, executive function); Supply Run (Keep Track, working memory updating); Riding Shotgun (visuospatial working memory); and Sentry Duty (dual n-back, working memory). There is also a meta-game in which players build a town using resources earned from the mini-games, played for 5 min each session.
Other Name: Mind Frontiers adaptive cognitive training - 48 sessions

Experimental: Fitness, Cognitive Training, sham tDCS
32 hours and 40 min of high-intensity cardiorespiratory fitness training (28 70-min sessions distributed over 16 weeks); 23 hours and 20 min of video game training with Mind Frontiers adaptive cognitive training software with simultaneous sham tDCS (20 70-min sessions distributed over weeks 5-16)
Behavioral: Fitness
Based on high intensity cardiovascular resistance training (HICRT), this intervention includes a combination of aerobic and strength training. Sessions are conducted in a group of ≤20 participants per class, with ≤5 participants per trainer. This intervention includes 28 70-min sessions (32.67 hrs) completed over 16 weeks: 3/wk weeks 1-4, 2/wk weeks 5-8, 1/wk weeks 9-16. At the first and last session, participants complete the Army Physical Readiness Test. All other sessions consist of: Warm-up; Walk/Run; 2 HICRT circuits with 3 sets of 3-4 exercises; 1-2 min jump rope and 4-min power series between HICRT segments; Drills & Skills; and Cool-down/stretch.
Other Names:
  • high intensity cardiovascular resistance training
  • aerobic and strength training

Device: sham tDCS
Sham HD-tDCS is administered during the first 30 minutes of each Mind Frontiers session. Therefore, the schedule is 20 30-min sessions (10 hrs) completed over 12 weeks: 1/wk weeks 5-8, 2/wk weeks 9-16. The HD-tDCS devices are Soterix Medical 2x2 models, using 4 electrodes (2 anodal and 2 cathodal). Electrodes are held in place with custom, 3D-printed electrode holders inserted into EEG caps, using EEG gel. Participants do not receive sustained stimulation; it is ramped up and ramped down over 30 sec at the beginning and end of the 30-min stimulation period to elicit the sensation of simulation and make the sham condition more convincing.
Other Name: sham high-definition transcranial direct current stimulation

Behavioral: Cognitive Training - 20 sessions
Mind Frontiers cognitive training software (Aptima Inc.) is a Wild West-themed Android application played on Nexus 10 tablets. This intervention includes 20 70-min sessions (23.33 hrs) completed over 12 weeks: 1/wk weeks 5-8, 2/wk weeks 9-16. The 6 mini-games, played in random order for 10 min each session, are Ante Up (Tower of London, executive functioning); Irrigator (visuospatial reasoning); Pen 'Em Up (dual task switching, executive function); Supply Run (Keep Track, working memory updating); Riding Shotgun (visuospatial working memory); and Sentry Duty (dual n-back, working memory). There is also a meta-game in which players build a town using resources earned from the mini-games, played for 5 min each session.
Other Name: Mind Frontiers adaptive cognitive training - 20 sessions

Experimental: Fitness, Cognitive Training, active tDCS
32 hours and 40 min of high-intensity cardiorespiratory fitness training (28 70-min sessions distributed over 16 weeks); 23 hours and 20 min of video game training with Mind Frontiers 1.0 adaptive cognitive training software with simultaneous active tDCS for a total of 10 hrs (20 70-min sessions distributed over weeks 5-16)
Behavioral: Fitness
Based on high intensity cardiovascular resistance training (HICRT), this intervention includes a combination of aerobic and strength training. Sessions are conducted in a group of ≤20 participants per class, with ≤5 participants per trainer. This intervention includes 28 70-min sessions (32.67 hrs) completed over 16 weeks: 3/wk weeks 1-4, 2/wk weeks 5-8, 1/wk weeks 9-16. At the first and last session, participants complete the Army Physical Readiness Test. All other sessions consist of: Warm-up; Walk/Run; 2 HICRT circuits with 3 sets of 3-4 exercises; 1-2 min jump rope and 4-min power series between HICRT segments; Drills & Skills; and Cool-down/stretch.
Other Names:
  • high intensity cardiovascular resistance training
  • aerobic and strength training

Device: active tDCS
Active HD-tDCS is administered during the first 30 minutes of each Mind Frontiers session. Therefore, the schedule is 20 30-min sessions (10 hrs) completed over 12 weeks: 1/wk weeks 5-8, 2/wk weeks 9-16. The HD-tDCS devices are Soterix Medical 2x2 models, using 4 electrodes (2 anodal and 2 cathodal). Electrodes are held in place with custom, 3D-printed electrode holders inserted into EEG caps, using EEG gel. Participants receive 2.0 mA current for 30 min, split over the 2 anodal electrodes, each drawing ≤1.0 mA. Stimulation is ramped up and ramped down over 30 sec at the beginning and end of the 30-min stimulation period.
Other Name: active high-def transcranial direct current stimulation

Behavioral: Cognitive Training - 20 sessions
Mind Frontiers cognitive training software (Aptima Inc.) is a Wild West-themed Android application played on Nexus 10 tablets. This intervention includes 20 70-min sessions (23.33 hrs) completed over 12 weeks: 1/wk weeks 5-8, 2/wk weeks 9-16. The 6 mini-games, played in random order for 10 min each session, are Ante Up (Tower of London, executive functioning); Irrigator (visuospatial reasoning); Pen 'Em Up (dual task switching, executive function); Supply Run (Keep Track, working memory updating); Riding Shotgun (visuospatial working memory); and Sentry Duty (dual n-back, working memory). There is also a meta-game in which players build a town using resources earned from the mini-games, played for 5 min each session.
Other Name: Mind Frontiers adaptive cognitive training - 20 sessions

Active Comparator: Active Control
56 hours of video game training with visual search and change detection tasks using open sesame software (48 70-min sessions distributed over 16 weeks)
Behavioral: Active Control
The active control condition consists of 2 tasks (change detection and visual search) with 3 variants each. This intervention includes 48 70-min sessions (56 hrs) completed over 16 weeks: 3/wk. The 6 tasks are played in random order for 10 min each session.
Other Name: Adaptive Visual Search/Change Detection

No Intervention: No Contact Control
Completed no study activities for 16 weeks after pre-assessment, then returned for post-assessment



Primary Outcome Measures :
  1. Change in Bochum Matrices Test [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    BOMAT is a non-verbal, one-dimensional neuropsychological test of Gf. The test consists of a series of 5x3 matrices of patternswith each matrix missing one field. The participant selects one of six possible answers that complete the matrix. The problems range from simple to complex and are all in black-and-white. Participants complete a 15-min practice and have 45 min to complete as many problems as they can (29 total).


Secondary Outcome Measures :
  1. Change in Letter Sets [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This test is a measure of Gf. For each problem of the Letter Sets task, the participant is shown 5 sets of letters, with 4 letters in each set. Four of the sets of letters follow a rule, while the fifth set of letters is different from the rest. With the exception of sounds of the sets of letters, shapes of the letters, or potential word formation of the letters, the participant must determine which rule applies to 4 of the letter sets and indicate the 1 letter set that doesn't fit. Participants have 7 minutes to complete as many problems as they can (15 total), with each problem getting progressively more difficult.

  2. Change in Number Series [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This test is a measure of Gf. Participants are shown a series of arithmetic number series and need to select the next number in the series from 5 possible answers at the bottom of the screen. The participant is given 5 practice problems at the beginning of instruction, and must complete as many problems as possible in 5 min (10 total).

  3. Change in Rotation Span [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a test of working memory. Participants must remember a series of arrows presented (16 possible arrows varying in length and direction), while maintaining accuracy on an interleaved letter rotation task (determining if a letter is facing the correct direction after rotation).

  4. Change in Symmetry Span [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a test of working memory. Participants must remember a series of blocks presented (from a 4x4 grid) while maintaining accuracy on an interleaved symmetry judgment task.

  5. Change in Reading Span [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a test of working memory. Participants must remember a series of words presented (18 possible 4-letter words) while maintaining accuracy on an interleaved task where they judge sensible or nonsensical sentences.

  6. Change in Garavan [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The Garavan task is a serial attention task that measures executive function, specifically task-switching ability. Participants are presented with a series of large and small squares, 10 series/trial in total. Subjects must keep a mental count of how many large and small squares have been presented. For each square, the participant rapidly updates this mental count and then presses the spacebar to see the next square. At the end of the sequence (length is random), a response screen appears and participants report their final count of large and small squares. On a given trial, 11-15 updates are made. Dependent measures are response time for consecutive trials of the same type (no-switch RT) and response time for consecutive trials that differ (switch RT). A cost RT metric can be computed by taking the difference between Switch and No-Switch RT as a measure of set shifting.

  7. Change in Stroop [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The Stroop task is a measure of executive function, specifically inhibition. In this task, subjects are asked to indicate the color of each word stimulus. The stimulus may be congruent (the word meaning and text color match), or incongruent (the word meaning and text color differ).

  8. Change in Keep Track [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The Keep Track task measures executive function, specifically updating items held in short-term memory. In the task, a series of word stimuli are presented, each belonging to a category. Subjects must remember only the last item presented from each category.

  9. Change in Immediate and Delayed Free Recall - Words [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a relational memory task. Participants are shown a sequence of 12 words (all 4-letter nouns/verbs), 750 ms for each word. Afterwards, the participant has 30 sec to enter as many words as they can remember from the trial. They do 1 practice trial, followed by 5 test trials. Approximately 20-30 min later, participants are given 90 sec to recall as many words as they can from all 5 previous trials.

  10. Change in Immediate and Delayed Free Recall - Pictures [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a relational memory task. Participants are shown a sequence of 12 images (all objects, no "action" images), 750 ms for each image. Afterwards, the participant has 30 sec to enter words to describe as many images as they recall from the trial (1 word/image). Each image has multiple words that could be accepted as a correct response (i.e., if shown an image of a chimpanzee, answers "chimpanzee" and "monkey" would both be acceptable). They do 1 practice trial of this task, followed by 5 test trials. Approximately 20-30 minutes later, the participant is given 90 sec to recall as many images as they can from all the previous trials.

  11. Change in Paired Associates [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This is a relational memory task. In Paired Associates, a list of 6 unrelated word pairs are presented. At recall, only the first word from each pair is presented. Subjects must enter the second word in the pair. This procedure is repeated with a second list of 6 word pairs. Approximately 20-30 minutes later, the first words from all 12 word pairs are presented. Subjects must enter the second words from each pair.

  12. Change in VO2 Max (relative, percentile) [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Aerobic fitness, defined as maximal oxygen consumption (VO2 max), is assessed using an indirect computerized calorimetry system during a modified Balke treadmill test. During the test, participants' heart rates are monitored using a Polar heart rate monitor, and ratings of perceived exertion are assessed every 2 min. During the test, speed remains constant while incline increases 2-3% every 2 min. Average O2 consumption and respiratory exchange ratio are sampled every 15 sec using a mouthpiece. Relative VO2 max is reported relative to body weight, calculated as ml O2/kg/min. Maximum effort is defined using at least 2 of the following: (1) age-defined maximum heart rate norms (HR > 85% of predicted max HR), (2) respiratory exchange ratio (CO2/O2) >1.1, (3) subjective rate of perceived exertion >17 (of 20), and (4) leveling of VO2 despite increasing aerobic demand. VO2 max percentile is also be reported based on age norms.

  13. Change in Body Mass Index [ Time Frame: 2 administrations: within 2 weeks before beginning and after finishing the 16-week intervention period ]
    BMI is calculated from measures of height and weight

  14. Change in brain structure [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    High-resolution structural MRI scan of brain anatomy using MPRAGE sequence, acquired in sagittal orientation (resolution: 0.9 mm, 192 slices, TR 1900 ms, TE 2.32 ms).

  15. Change in BOLD signal at rest [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Using functional MRI to measure blood-oxygen-level-dependent signal while the subject is at rest and not performing a task

  16. Change in BOLD signal during task [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Functional MRI that measures brain activity (based on hemodynamic response and blood-oxygenation-level dependent signal) during an experimental task.

  17. Change in Object Location Task performance [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Completed during fMRI scanning. In the task, an image with 4 objects is presented on a grid of 9 possible locations. Participants are instructed to memorize the spatial locations of all 4 objects and mentally rotate the grid 90⁰. Participants are then presented with a probe image containing the same 4 objects rotated 90⁰. Participants must indicate whether or not any of the objects changed location in the rotated probe image. There are three possible responses: either all objects match; 1 object moves to a new location; or 2 objects swap locations. This task is a measure of relational memory.

  18. Change in 3-back Task performance [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Completed during fMRI scanning. Participants are presented with a continuous stream of stimuli (either faces or words), and for every stimulus, the participant must indicate (yes/no) whether or not the current stimulus is the same as the one presented three trials back. This task is a measure of working memory.

  19. Change in Diffusion of Water in the brain [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Diffusion tensor imaging (DTI) is a magnetic resonance imaging method that is sensitive to the diffusion of water molecules. Diffusion of water in the brain depends on the tissue type, structural architecture, and presence/absence of barriers within imaging voxels. Using this raw imaging information, diffusion-based properties can be estimated including: 1. fractional anisotropy (FA), which is a measure of whether or not the 3-dimensional diffusion is largely directional (e.g., within an axon; thus, anisotropic diffusion), or if the diffusion is equal in all directions (e.g., within CSF; thus isotropic diffusion); 2. radial diffusivity (RD), which is a measure of how diffusion in the plane transverse to the principal direction of diffusion (i.e., within a cross-section of an axon, rather than down the length of an axon).

  20. Change in single-voxel magnetic resonance spectroscopy (MRS) [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Technique to measure cell metabolites within a single super voxel of the brain (20 mm3), such as N-acetyl aspartate (NAA)

  21. Change in Cerebral Blood Flow [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    During magnetic resonance imaging scans, using the arterial spin labeling technique to acquire multi-slice cerebral blood flow maps

  22. Saliva-based Genetic Biomarkers [ Time Frame: One administration, within a week after finishing the 16-week intervention ]
    Saliva collected from passive drooling, to be analyzed for biomarkers related to fluid intelligence

  23. Height [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Height measured to calculate BMI estimate

  24. Weight [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Weight measured to calculate BMI estimate

  25. Change in Demographics Questionnaire [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Questionnaire that requests age, birth date, sex, race/ethnicity, occupation.

  26. Change in Big Five Inventory (BFI) Questionnaire [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    Personality assessment with five dimensions: openness, conscientiousness, extraversion, agreeableness, and neuroticism

  27. Change in Grit Scale Questionniare [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This questionnaire assesses the personality trait of grit, a characteristic associated with passion and adherence to long-term goals, along with strong motivation to achieve goals despite potential obstacles.

  28. Change in Pittsburgh Sleep Quality Index (PSQI) [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The PSQI assesses sleep habits on eight dimensions over the past month with 11 open-ended and multiple choice questions. Relevant dimensions include sleep duration, disturbance, latency, day dysfunction, efficiency, quality, use of medications to sleep, and an overall binary score of sleep habits.

  29. Change in Godin-Shepard Leisure Time Physical Activity Questionnaire [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This survey asks about level of physical activity during leisure time in the past month, from which longer-term exercise habits can be extrapolated. By collecting height, weight, and resting heart rate with this measure, a VO2 max estimation can be reliably calculated.

  30. Change in UCLA Loneliness Scale [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This survey asks about the frequency (never, rarely, sometimes, often) of 20 statements regarding feelings of loneliness and social connection.

  31. Change in Need for Cognition [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    This survey asks 45 Likert-type questions regarding the value an individual places upon cognition in daily life.

  32. Change in Implicit Theories of Intelligence Survey (ITIS) [ Time Frame: 2 administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The ITIS asks 8 Likert-type questions regarding personal beliefs about the relative fixedness/malleability of intelligence.

  33. Physical Activity Enjoyment Scale [ Time Frame: Administered once, within a week after finishing the 16-week intervention period ]
    The Physical Activity Enjoyment Scale (PACES) measures individuals' enjoyment with their current activity level.

  34. Post-Experiment Survey [ Time Frame: Administered once, within 2 weeks after finishing the 16-week intervention period ]
    This survey was customized for each arm to assess: participant feedback on the various interventions they experienced; strategies developed and used in cognitive training and active control training; expectancy effects of video game-training, physical fitness training, and mindfulness meditation training; and the contribution of external (outside-study) physical activity/exercise and video game play.

  35. Preference for and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q) [ Time Frame: Two administrations: within a week before beginning and after finishing the 16-week intervention period ]
    The Preference and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q) measures individuals' preferences for physical activity type and duration. For instance, does one prefer high-intensity activity for a brief period of time, or low-intensity activity for a longer duration? How does one respond to physical challenge and exhaustion?

  36. Game Feedback - Mind Frontiers [ Time Frame: Administered at Sessions 1, 20 (or 24), and 48 of the Mind Frontiers intervention ]
    Game feedback surveys were developed in-house and administered to evaluate participant responses to cognitive training. These surveys were administered at Sessions 1, 24, and 48 for the 48-session intervention, or at Sessions 1 and 20 for the 20-session intervention. These surveys evaluated enjoyment, engagement, motivation, demand, and frustration with each mini-game.

  37. Game Feedback - Active Control [ Time Frame: Administered at Sessions 1, 24, and 48 of Active Control intervention ]
    Game feedback surveys were developed in-house and administered to evaluate participant responses to active control training. These surveys evaluated enjoyment, engagement, motivation, demand, and frustration with each task.

  38. Army Physical Readiness Test (APRT) [ Time Frame: Administered at Session 1 and Session 28 of the fitness intervention ]
    The APRT is five exercises: (1) 60-yard shuttle run, (2) standing long jump, (3) one-minute of rowers, (4) one-minute of push-ups, and (5) a 1.5 mile run

  39. Heart rate [ Time Frame: Data collected continuously during at all 28 fitness intervention sessions ]
    Participants' heart rates were monitored using Polar heart rate monitor E600 during all sessions of the fitness intervention



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 44 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • English fluency
  • US citizen, US permanent resident, or student/work visa sponsored by UIUC
  • Available for 18-20 weeks
  • Ages 18 - 44
  • Normal or corrected-to-normal vision
  • Normal or corrected-to-normal hearing

Exclusion Criteria:

  • Previous participant in studies with similar protocols
  • Currently taking any medication affecting CNS
  • Has taken medication affecting CNS in past 2 months
  • Current or planned pregnancy
  • Recurrent migraines
  • Concussion in past 2 years
  • History of stroke
  • History of epilepsy/seizures
  • Any medical condition affecting CNS (e.g., history of thyroid cancer)
  • Any medical condition affecting capability to exercise (e.g., paralysis)
  • Reading disability/dyslexia
  • Prior brain surgery
  • Known brain malformation
  • Colorblindness
  • Heart condition that requires physician approval for physical activity
  • Chest pain (with OR without physical activity)
  • Loss of balance/dizziness/loss of consciousness
  • Bone or joint problem that could be made worse by a change in physical activity
  • Medication for blood pressure or a heart condition

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02780739


Locations
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United States, Illinois
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States, 61801
Sponsors and Collaborators
University of Illinois at Urbana-Champaign
The City College of New York
Aptima, Inc.
Georgia Institute of Technology
Circinnus LLC
Autonomous University of Madrid, Spain
Investigators
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Principal Investigator: Aron K Barbey, Ph.D. University of Illinois at Urbana-Champaign
Principal Investigator: Arthur F Kramer, Ph.D. Northeastern University
Principal Investigator: Neal J Cohen, Ph.D. University of Illinois at Urbana-Champaign
Principal Investigator: Charles H Hillman, Ph.D. University of Illinois at Urbana-Champaign

Additional Information:
Publications of Results:
Baumgartner, NW, Covello, AR, Reeser, GE, Cohen, NJ, Kramer, AF, Barbey, AK, Hillman, CH, Khan, NA. Moderate to vigorous physical activity influences aerobic capacity independent of body composition. Poster session presented at: American College of Sports Medicine 2016 Conference; 2016 Jun; Boston, MA.
Covello, A, Baumgartner, NW, Curran, MR, Reeser, GE, Cohen, NJ, Kramer, AF, Hillman, CH, Barbey, AK, Khan, NA. The sexual dimorphic relationship between dietary fiber intake and visceral adipose tissue. Abstract accepted to: Experimental Biology 2016 Meeting; 2016 Apr; San Diego, CA.

Other Publications:
Hossip, R, Turck, D, Hasella, A. Bocumer Matrizentest: BOMAT-Advanced-Short Version. Göttingen: Hogrefe Ltd; 1999.
Moody, DE. Can intelligence be increased by training on a task of working memory? Intelligence. 2009; 37(4):327-328.
French, JW, Harmann, HH, Dermen, D. Manual for kit of factor-referenced cognitive tests. New Jersey: Educational Testing Service; 1976. p. 109-113
Bernreuter, RG, Goodman, CH. A study of the Thurstone Primary Mental Abilities Tests applied to freshman engineering students. J Exp Psychol Gen. 1941; 32(1):55-60.
Stroop, JR. Studies of inference in serial verbal reactions. J Exp Psychol. 1935;18(6):643-662.
American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins; 2010.
John, O, Donahue, EM, Kentle, RL. The Big Five Inventory - Versions 4a and 54. Berkeley, CA: University of California Institute of Personality and Social Research; 1991.
Cacioppo, JT, Petty, RE. The need for cognition. J Pers Soc Psychol. 1982; 42(1): 116.
Kendzierski, D, DeCarlo, KJ. Physical Activity Enjoyment Scale: Two validation studies. J Sport Exerc Psych. 1991; 13(1): 50-64.
Ekkekakis, P, Hall, E, Petruzello, SJ. Some like it vigorous: Measuring individual differences in the preference for and tolerance of exercise intensity. J Sport Exerc Psych. 2005; 27, 350-374.

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Responsible Party: University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier: NCT02780739     History of Changes
Other Study ID Numbers: 2014-1312170004-Ph1a
14212 ( Other Identifier: UIllinoisUC IRB )
First Posted: May 23, 2016    Key Record Dates
Last Update Posted: May 23, 2016
Last Verified: May 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Plan Description: Aggregate data will be shared. Details of individual participant data to be shared are still under discussion.

Keywords provided by University of Illinois at Urbana-Champaign:
Psychological Tests
Neuropsychological Tests
Transcranial Direct Current Stimulation
Exercise
Circuit-Based Exercise
Video Games
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Cognition
Executive Function
Learning
Problem Solving
Transfer (Psychology)
Decision Making
Brain
Gray Matter
White Matter