Dental Erosion in Patients With Gastro-oesophageal Reflux
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|ClinicalTrials.gov Identifier: NCT02775149|
Recruitment Status : Suspended (No participants)
First Posted : May 17, 2016
Last Update Posted : November 6, 2020
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions.
The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
|Condition or disease||Intervention/treatment|
|Dental Erosion||Other: Collection of saliva samples Other: Visual detection of BEWE-index|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Dental Erosion in Patients With Gastro-oesophageal Reflux|
|Actual Study Start Date :||November 1, 2016|
|Estimated Primary Completion Date :||December 2021|
|Estimated Study Completion Date :||December 2021|
Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons
Other: Collection of saliva samples
Collection of saliva samples
Other: Visual detection of BEWE-index
Visual detection of BEWE-index
- Visual assessment of the BEWE-(basic erosive wear examination)-index [ Time Frame: After removal of the probe (on second day) ]
- Determination of unstimulated and stimulated saliva flow rate (ml/min). [ Time Frame: While wearing the probe at three time points over 24h: morning, noon, evening ]
- Determination of saliva pH and buffer capacity (mol/L). [ Time Frame: While wearing the probe at three time points over 24h: morning, noon, evening ]
- Determination of total protein content in saliva (g/L). [ Time Frame: While wearing the probe at three time points over 24h: morning, noon, evening ]
- Determination inorganic calcium and phosphate in saliva (mmol/L). [ Time Frame: While wearing the probe at three time points over 24h: morning, noon, evening ]
- Measurement of salivary enzyme activity: Protease, Kollagenase/Gelatinase, Pepsin, Trypsin, and Amylase (U/mL). [ Time Frame: While wearing the probe at three time points over 24h: morning, noon, evening ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02775149
|Principal Investigator:||Annette Wiegand, Prof. Dr. med. dent.||Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany|