AsthMatic Inflammation and Neurocircuitry Activation (MINA) (MINA)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02764437|
Recruitment Status : Recruiting
First Posted : May 6, 2016
Last Update Posted : October 16, 2017
|Condition or disease||Intervention/treatment||Phase|
|Allergic Asthma||Biological: Whole lung antigen challenge, segmental allergen challenge||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||AsthMatic Inflammation and Neurocircuitry Activation (MINA)|
|Actual Study Start Date :||July 28, 2016|
|Estimated Primary Completion Date :||March 2021|
|Estimated Study Completion Date :||March 2021|
MRI-Bronch, PET-WLAC (Stress vs Control)
Subjects will have a functional MRI scan 24 hours before a bronchoscopy with segmental allergen challenge. 48 hours post segmental allergen challenge, the subject will have another MRI and bronchoscopy. 4-6 weeks later, subjects will have a PET scan and whole lung antigen challenge under a stress condition or control condition. 4-6 weeks later, subject will have another PET scan and whole lung antigen challenge under a stress condition or control condition (whatever they did not have the first time).
Biological: Whole lung antigen challenge, segmental allergen challenge
Whole lung antigen challenge with housedust mite, short ragweed or cat hair allergen extracts. Segmental allergen challenge with housedust mite, short ragweed or cat hair allergen extracts.
Other Name: House dust mite, short ragweed, cat hair allergen extracts
- Bronchoalveolar Eosinophils pre vs post antigen challenge [ Time Frame: 48 hours ]The percent of eosinophils will be measured from the Bronchoalveolar lavage fluid pre segmental allergen challenge and will be measured 48 hours post segmental allergen challenge.
- Sputum Eosinophils pre stress condition vs post stress condition [ Time Frame: 72 hours ]The percent of eosinophils will be measured from the sputum fluid pre stress condition and will be measured up to 72 hours later (post stress condition).
- Sputum Eosinophils pre control condition vs post control condition [ Time Frame: 72 hours ]The percent of eosinophils will be measured from the sputum fluid pre control condition and will be measured up to 72 hours later (post control condition).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02764437
|Contact: Danika Klaus, BSNfirstname.lastname@example.org|
|Contact: Gina Crisafi, BSemail@example.com|
|United States, Wisconsin|
|UW Madison School of Medicine and Public Health||Recruiting|
|Madison, Wisconsin, United States, 53792|
|Contact: Danika Klaus, BSN 608-263-0524 firstname.lastname@example.org|
|Contact: Gina Crisafi, BS 608-265-4554 email@example.com|
|Principal Investigator: William W Busse, MD|
|Principal Investigator:||William Busse, MD||UW Madison|