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Expression of HOXA10 and HOXA11 in the Endometrium of Infertility Patients With an Endometrial Polyp Before and After Polypectomy

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ClinicalTrials.gov Identifier: NCT02761278
Recruitment Status : Unknown
Verified May 2016 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : May 4, 2016
Last Update Posted : May 12, 2016
Sponsor:
Information provided by (Responsible Party):
Hillel Yaffe Medical Center

Brief Summary:
The aim of this study is to measure the expression of HOXA10 and HOXA11 in the endometrium of infertility patients with an endometrial polyp before and after polypectomy. HOXA10 and HOXA11 are well-established markers of implantation. It is uncertain as to whether an endometrial polyp interferes with embryo implantation. A higher expression of HOXA10 and HOXA11 after polypectomy can indicate that endometrial polyp does interfere with embryo implantation.

Condition or disease Intervention/treatment Phase
Infertility Procedure: Endometrial biopsy Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : July 2016
Estimated Primary Completion Date : July 2017
Estimated Study Completion Date : July 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Infertility

Arm Intervention/treatment
Active Comparator: HOXA10 and HOXA11 Expression Before Polypectomy
A biopsy will taken in infertility patients with endometrial polyp before polypectomy
Procedure: Endometrial biopsy
Active Comparator: HOXA10 and HOXA11 Expression After Polypectomy
A biopsy will taken in infertility patients with endometrial polyp 1-3 months after polypectomy
Procedure: Endometrial biopsy



Primary Outcome Measures :
  1. Comparison of amounts of HOXA10 and HOXA11 expressed before and after polypectomy [ Time Frame: Four months ]


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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Infertile women with endometrial polyp

Exclusion Criteria:

  • Endometriosis
  • Polycystic ovary syndrome
  • Hydrosalpinx
  • Sub-mucus myoma
  • Women who have taken hormonal therapy in the preceding month

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02761278


Contacts
Contact: Guy Shrem, MD dr.shremguy@gmail.com

Sponsors and Collaborators
Hillel Yaffe Medical Center
Investigators
Principal Investigator: Guy Shrem, MD Hillel Yaffe Medical Center

Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT02761278     History of Changes
Other Study ID Numbers: HYMC-0039-16
First Posted: May 4, 2016    Key Record Dates
Last Update Posted: May 12, 2016
Last Verified: May 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Infertility
Genital Diseases, Male
Genital Diseases, Female