Impact of Maternal Stress on Infant Stunting
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|ClinicalTrials.gov Identifier: NCT02755012|
Recruitment Status : Completed
First Posted : April 28, 2016
Last Update Posted : April 28, 2016
|Condition or disease|
|Maternal; Malnutrition Infant Malnutrition Physiological Stress Emotional Stress Life Stress Domestic Violence Infection Breast Feeding Mastitis|
Grounded in participatory action research and a socio-ecological framework, this mixed-methods, observational study enrolled a longitudinal cohort of 155 women, seen during pregnancy (6-9 mo), early (0-6 wks) and later (4-6 mo) postpartum, and two cross-sectional cohorts (60 early, 56 later postpartum).
Maternal and infant anthropometry was recorded, maternal fecal, urine and saliva samples were collected, and questionnaires were used to explore household factors (socioeconomic status, food security), social factors (autonomy, paternal/social support, domestic violence), and maternal-level factors (nutrition, infection, emotional distress).
Analyses focused on (1) characterizing women's exposure to nutrition, infection and psychosocial stressors vs. resilience factors, (2) describing the maternal diurnal salivary cortisol rhythm in pregnancy and postpartum and explore its association with psychosocial variables, (3) assessing the cumulative impact of maternal-level factors (nutritional, infectious, psychosocial), social factors (autonomy, social support, domestic violence), and household factors (socioeconomic status, food security) on early infant growth, and (4) evaluating whether maternal cortisol may be a mediator in the vertical transmission of stress.
In addition, Photovoice activities involved giving a camera to 23 women from study communities, who documented sources of stress vs. resilience for local women, and shared photo-elicited narratives through six group sessions.
|Study Type :||Observational|
|Actual Enrollment :||271 participants|
|Official Title:||Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting|
|Study Start Date :||June 2012|
|Actual Primary Completion Date :||November 2013|
|Actual Study Completion Date :||November 2013|
155 women enrolled in 2nd or 3rd trimester of pregnancy, and seen again, with their infant, at 0-6 wk postpartum, and 4-6 mo postpartum
60 women enrolled at 0-6 wk postpartum and seen once with their infant (cross-sectional)
56 women enrolled at 0-6 wk postpartum and seen once with their infant (cross-sectional)
- Infant stunting (Infant height-for-age score) [ Time Frame: 0-6 wk ]Infant height-for-age score measured at 0-6 wk
- Infant stunting (Infant height-for-age score) [ Time Frame: 4-6 mo postpartum ]Infant height-for-age score measured at 4-6 mo postpartum
- Change in infant HAZ per month [ Time Frame: Change over time (between 0-6wk and 4-6mo) ]Change in infant HAZ score between 1st (0-6 wk) and 2nd (4-6 mo) visits
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02755012
|Principal Investigator:||Anne Marie Chomat, MD, PhD, MPH||McGill University|