Genetic Basis of Rosacea Study (Control)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02749786
Recruitment Status : Recruiting
First Posted : April 25, 2016
Last Update Posted : September 17, 2018
Information provided by (Responsible Party):
Anne Chang, Stanford University

Brief Summary:
Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. It it considered to be a syndrome encompassing various combinations of cutaneous signs including flushing, erythema, telangiectasia, papules, edema, ocular lesions, and rhinophyma. The exact etiology of cutaneous rosacea is unknown but is characterized by persistent vasodilation, increased vascular permeability, and vascular hyper-reactivity of the microcirculation of the central part of the face. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigator hopes to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.

Condition or disease Intervention/treatment Phase
Rosacea Other: Skin Biopsy Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Expansion Arm of Papulopustular Rosacea Gene Expression Profiling to Include Normal Individuals as Anatomic Site Specific Controls
Study Start Date : October 2015
Estimated Primary Completion Date : November 2019
Estimated Study Completion Date : November 2019

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Control Group
Ten participants who does not have rosacea will be used as the control group.
Other: Skin Biopsy
Skin biopsies will be performed via the Keys punch technique from normal facial skin.

Primary Outcome Measures :
  1. Gene expression profile of papulopustular rosacea compared to normal skin and skin from individuals without rosacea. [ Time Frame: Up to 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion criteria include:

  1. Fitzpatrick skin type II or III
  2. Age greater than or equal to 18 years
  3. Individuals without a history of rosacea

Exclusion criteria include:

  1. Women who are pregnant or lactating
  2. Use of topical prescription medications or procedures to the face within one month of enrollment
  3. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02749786

Contact: Anne L Chang, MD 650 721 7151

United States, California
Stanford Dermatology Recruiting
Redwood City, California, United States, 94603
Contact: Anne Chang, MD    650-721-7151   
Sponsors and Collaborators
Stanford University
Principal Investigator: Anne Chang Stanford University

Responsible Party: Anne Chang, Associate Professor of Dermatology, Stanford University Identifier: NCT02749786     History of Changes
Other Study ID Numbers: 22419
First Posted: April 25, 2016    Key Record Dates
Last Update Posted: September 17, 2018
Last Verified: September 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Skin Diseases