Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture
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|ClinicalTrials.gov Identifier: NCT02749409|
Recruitment Status : Terminated (Case numbers not enough, however, the funding is over)
First Posted : April 25, 2016
Last Update Posted : January 31, 2020
|Condition or disease||Intervention/treatment||Phase|
|Parecoxib Rib Fractures||Drug: Parecoxib Drug: Morphine||Phase 3|
3.1 Inclusion/exclusion criteria Patients who are diagnosed ribs fracture and need admission. Exclusion criteria included heart failure, Coronary artery disease (CAD) history. Traumatic cardiac injury and cardiac tamponade will be excluded, too.
3.2 Group design Patients will be divided two groups, and the experimental group will be given parecoxib after visiting emergency department. And they will be kept given after admission by intravenous method every 12 hours for 4 days. The control group will be given Narcotic agent such as morphine for pain control. The daily dose will be recorded. Finally the end outcome will be recorded.
3.3 Data collection The data of patient's medical history and laboratory results will be recorded on pre-designed case report forms (CRFs) by study nurses. In all patients, age, gender, diagnosis, co-morbidities, length of hospital and intensive care unit (ICU) stay, Injury Severity Score (ISS) score, numerical rating scale (NRS) and outcomes, will be recorded. In addition, all microorganisms isolated and antibiotic substances applied will be documented.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture|
|Actual Study Start Date :||August 8, 2016|
|Actual Primary Completion Date :||July 10, 2018|
|Actual Study Completion Date :||July 20, 2018|
Active Comparator: Control group
The control group will be given Morphine prn after admission
Experimental: Experimental group
the experimental group will be given parecoxib after admission by intravenous method every 12 hours for 4 days. Then Morphine agent will be given prn usage
- all cause mortality [ Time Frame: 1 year ]