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Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency (TSASDI)

This study is not yet open for participant recruitment.
See Contacts and Locations
Verified April 2016 by University Hospital, Strasbourg, France
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT02747056
First received: March 7, 2016
Last updated: April 18, 2016
Last verified: April 2016
  Purpose
The research aims at clarifying the impact of autism on personal identity in adulthood. Two studies will be made in order to compare adults with autistic spectrum disorders without intellectual deficiency and controls. In the first study (Study A), the investigators will ask subjects to tell autobiographical memories and to specify their characteristics by answering focused questions. In the second study (Study B), the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.

Condition Intervention
Autism Spectrum Disorders Other: clinical, psychological and neuropsychological assessment Other: Autobiographical memories Assessment Other: Autobiographical memories assessment characteristics

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Primary Outcome Measures:
  • The number of details in the memory (A)/The specificity of the memory (B) [ Time Frame: The number of details or the specificity of the memory is assessed from 1 day to 3 months after the inclusion/baseline ]

    study A:The number of details is the total number of perceptual/sensory, temporal, contextual, emotional and cognitive details found in the memory after spontaneous recall first. Secondly, the investigators will ask subjects to clarify the five characteristics of the details presented upper and retrieval should be make easier with specific cueing.

    Study B:The specificity measures how the memory is focused on specific date, space, context, emotions, thoughts and feelings. The specificity of the memories is deeply linked to the self .



Secondary Outcome Measures:
  • Study A and B: Autistic symptoms questionnaire 1 [ Time Frame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1 ]
    Autistic symptoms are assessed through the Ritvo's Autism Asperger Diagnostic Scale. A numerical value will be obtained for this questionnaire.

  • Study A and B: Autistic symptoms questionnaire 2 [ Time Frame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1 ]
    Autistic symptoms are assessed through the Empathy Quotient. A numerical value will be obtained for this questionnaire.

  • Study A and B: Autistic symptoms questionnaire 3 [ Time Frame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1 ]
    Autistic symptoms are assessed through the Autistic Quotient. A numerical value will be obtained for this questionnaire.

  • Study A and B:Executives functions, test 1 [ Time Frame: Executives functions will be assessed during the initiation/baseline visit (V1) ]
    Executive functions are measured through test: the Trail Making Test A & B, The test will provide value in seconds. This executive functions are known to be impaired in autism spectrum disorder and to be involved in autobiographical memory.

  • Study Aand B:Executives functions test 2 [ Time Frame: Executives functions will be assessed during the initiation/baseline visit (V1) ]
    Executive functions are measured through test: The Hayling test . The tests will provide value in seconds. This executive functions are known to be impaired in autism spectrum disorder and to be involved in autobiographical memory.

  • Study A and B:Executives functions test 3 [ Time Frame: Executives functions will be assessed during the initiation/baseline visit (V1) ]
    Executive functions are measured through test: The phonologic verbal fluency tasks. The test will give numerical value. These executive functions are known to be impaired in autism spectrum disorder and to be involved in autobiographical memory.

  • Study A and B: The self concept, questionnaire 1 [ Time Frame: self-concept will be assessed during the initiation/baseline visit (V1) ]
    The self-concept is measured through the questionnaire like the Thinking About Life Experiences (TALE) scale. This test measure how the self is updated and adaptable. A numerical value will be obtained for the questionnaire.

  • Study A and B: The self concept, questionnaire 2 [ Time Frame: self-concept will be assessed during the initiation/baseline visit (V1) ]
    The self-concept is measured through the questionnaire like: The Self Concept Clarity Scale. This test measure how the self is updated and adaptable. A numerical value will be obtained for the questionnaire.

  • Study A and B: The self concept, questionnaire 3 [ Time Frame: self-concept will be assessed during the initiation/baseline visit (V1) ]
    The self-concept is measured through the questionnaire like : The Rosenberg self-esteem test. This test measure how the self is updated and adaptable. A numerical value will be obtained for the questionnaire.

  • Study A: the number of remember/ know/ guess responses, the perspective in recollection and the subjective temporal distance in the memory [ Time Frame: This outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1 ]

    The number or remember, know, guess responses gives information about the subjective state of conscious awareness during the recall of the memory. This subjective state goes from complete conscious recollection with reliving of thoughts, perceptions, and feelings at the date of the event to a vague impression.

    The perspective in recollection could be an actor perspective or an observer perspective. In the actor perspective, the recollection is in a first-person point of view. The person remembering relives the event through her own eyes. In the observer perspective, the recollection is in a third-person point of view. The person remembering sees the scene of the memory as the spectator of herself.

    The subjective temporal distance is the subjective perception of the temporal distance between the present and the event of the memory. The investigators will ask subjects if they feel this event close or distant on a seven point scale.


  • Study B:The importance for the self of the memory test1 [ Time Frame: This outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description ]
    The importance for the self of the memory is assessed by distinctiveness. The distinctiveness criteria of the memory is established by Conway. These criteria require participants to specify in what extent these memories have had a personal significance, were discriminatory, consistent and are frequently recalled. A numerical value will be obtained for this criteria.

  • Study B:The importance for the self of the memory test 2 [ Time Frame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description ]
    The importance for the self of the memory is assessed by emotional intensity. The emotional intensity will be measured with the PANAS scale. The investigator will ask the participants to rate the emotional intensity of their memory based on 4 positive affect (determined, enthusiastic, proud and strong) and 4 negative affect (frightened, ashamed, guilty and disappointed). No value is obtained.

  • Study B:The importance for the self of the memory test 3 [ Time Frame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description ]
    The importance for the self of the memory is assessed by the active or passive position . An active position will refer to a memory in which the subject plays a key role in the progression of the event. A passive position will refer to a memory where the participant undergoes an event where he did not play a determining role.

  • Study B:The importance for the self of the memory test 4 [ Time Frame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description ]
    The importance for the self of the memory is assessed by the emotional valence of memory. The emotional valence of memory will be etheir positive, negative or neutral.


Estimated Enrollment: 104
Study Start Date: June 2016
Estimated Study Completion Date: December 2019
Estimated Primary Completion Date: September 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Autism spectrum disorder studyA part1
The subjects will perform clinical, psychological and neuropsychological assessment. the subjects will do 3 tests about executive functions. Finally, the participants will complete 3 questionnaires about autism and 3 questionnaires about the self concept.
Other: clinical, psychological and neuropsychological assessment
the subjects will do 3 tests about executive functions, complete 3 questionnaires about autism and 3 questionnaires about the self concept
Experimental: Autism spectrum disorder studyA part2
The subjects will perform Autobiographical memories Assessment. The subjects will tell autobiographical memories freely first and secondly by answering focused questions to specify the characteristics of subjects' memories
Other: Autobiographical memories Assessment
The investigators will ask subjects to tell autobiographical memories freely first and, secondly, to specify participants'characteristics by answering focused questions.
Control adults Study A, part 1
The subjects will perform clinical, psychological and neuropsychological assessment. The subjects will do 3 tests about executive functions. The participants will complete 3 questionnaires about autism and 3 questionnaires about the self concept.
Other: clinical, psychological and neuropsychological assessment
the subjects will do 3 tests about executive functions, complete 3 questionnaires about autism and 3 questionnaires about the self concept
Control adults Study A, part 2
The subjects will perform Autobiographical memories Assessment. The subjects will tell autobiographical memories freely first and secondly by answering focused questions to specify the characteristics of subjects' memories
Other: Autobiographical memories Assessment
The investigators will ask subjects to tell autobiographical memories freely first and, secondly, to specify participants'characteristics by answering focused questions.
Experimental: Autism spectrum disorder Study B, part 1
The subjects will perform clinical, psychological and neuropsychological assessment. The subjects will do 3 tests about executive functions. The participants will complete 3 questionnaires about autism and 3 questionnaires about the self concept.
Other: clinical, psychological and neuropsychological assessment
the subjects will do 3 tests about executive functions, complete 3 questionnaires about autism and 3 questionnaires about the self concept
Experimental: Autism spectrum disorder Study B, part 2
The subjects will perform Autobiographical memories assessment characteristics. The subjects will say the self statements which define them. Then, the participants will have to tell and specify the characteristics of the autobiographical memories linked to the self statements.
Other: Autobiographical memories assessment characteristics
During the second time point, the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.
Control adults, Study B part 1
The subjects will perform clinical, psychological and neuropsychological assessment.The subjects will do 3 tests about executive functions. Finally, the participants will complete 3 questionnaires about autism and 3 questionnaires about the self concept.
Other: clinical, psychological and neuropsychological assessment
the subjects will do 3 tests about executive functions, complete 3 questionnaires about autism and 3 questionnaires about the self concept
Control adults, Study B part 2
The subjects will perform Autobiographical memories assessment characteristics. The subjects will say the self statements which define them. Then, the participants will have to tell and specify the characteristics of the autobiographical memories linked to the self statements
Other: Autobiographical memories assessment characteristics
During the second time point, the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.

Detailed Description:

Introduction:

Autism associates impairments in social relationships and specific competencies linked to restricted interests. These interests usually focus on mathematics, drawings or foreign language learning and are very significant in the autobiographies of persons with autism without intellectual deficiency. It's seem to be a basement of their self-identity. The personal identity relies on both the self representations and the sense of self. This sense of self supports the self continuity through time which links the present feelings, the autobiographical memories and the future personals projects. The personal identity depends on the memory of life events called "autobiographical memory."

Objectives:

The research aims at clarifying the impact of autism on personal identity in adulthood. Two studies will be made in order to compare adults with autistic spectrum disorders without intellectual deficiency and controls. In the first study (Study A), the investigators will ask subjects to tell autobiographical memories and to specify their characteristics by answering focused questions. In the second study (Study B), the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.

Expected Results:

The first study will inform the investigators on the sense of self and self continuity through time. The investigators predict that it would be difficult for subjects with autism spectrum disorders to give details of their life events. The focused questions should make easier the recollection of the memories. The investigators hypothesize that the memories linked to the typically autistic restricted interests would be more detailed.

The second study will inform the investigators on the memories linked to self representations. The investigators predict that these memories would be, in autism, less detailed and less important for identity. The investigators also hypothesize that the memories linked to the restricted interests would be more detailed and important for the self.

Autobiographical memory and socialization are deeply interconnected. So, the investigators think that this research will help them to elaborate news therapies focused on autobiographical memory improvement. Finally, the investigators want to reduce the social disability in autism.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Study A & B, Adults with autism spectrum disorders without intellectual deficiency

Inclusion criteria:

  • adults with autism spectrum disorders
  • 18 to 65 years old

Exclusion criteria:

  • treatment with benzodiazepines

Study A & B, control adults

Inclusion criteria:

  • healthy volunteers
  • 18 to 65 years old

Exclusion criteria:

  • psychiatric disorders
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02747056

Contacts
Contact: Jean Marie DANION, Prof 3 88 11 60 37 ext +33 Jean-Marie.DANION@chru-strasbourg.fr
Contact: Romain COUTELLE, MD 3 88 11 59 52 ext +33 romain.coutelle@chru-strasbourg.fr

Locations
France
Hôpitaux universitaires de Strasbourg Not yet recruiting
Strasbourg, France, 67091
Contact: Jean Marie DANION, Professor    3 88 11 60 37 ext +33    Jean-Marie.DANION@chru-strasbourg.fr   
Contact: Romain COUTELLE, Doctor    3 88 11 59 52 ext +33    romain.coutelle@chru-strasbourg.fr   
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Principal Investigator: Jean Marie DANION, Prof Hôpitaux Universitaires de Strasbourg
  More Information

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT02747056     History of Changes
Other Study ID Numbers: 6282
Study First Received: March 7, 2016
Last Updated: April 18, 2016
Individual Participant Data  
Plan to Share IPD: No

Additional relevant MeSH terms:
Disease
Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Pathologic Processes
Neurodevelopmental Disorders
Mental Disorders

ClinicalTrials.gov processed this record on June 28, 2017