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Motivation and Executive Control in Schizophrenia

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ClinicalTrials.gov Identifier: NCT02734927
Recruitment Status : Completed
First Posted : April 12, 2016
Last Update Posted : April 26, 2018
Sponsor:
Information provided by (Responsible Party):
Hôpital le Vinatier

Brief Summary:

In order to control a behaviour, investigators need to realise goal directed actions and to priories some actions. This control is required in unusual situation. Appropriate actions are selected and coordinated according to context and aim.

Several studies try to draw a model of executive function. Recently, Koechlin has suggested a three levelled organisation to explain how the prefrontal cortex controls actions.

Contextual control is useful to answer appropriately with the immediate context. Episodic control allows selecting the action according to specific information given before. Sensorial control is the automatic response when a stimulus is presented.

Some diseases like schizophrenia are associated with neurological dysfunction in prefrontal cortex. Chambon and al (2008) have identified a dysfunction of contextual control in schizophrenia.

As the prefrontal cortex is involved in motivational process, it seems interesting to study potential links between executive function and motivation. A study from Kouneiher shows contextual and episodic activation of motivation in healthy population.

Investigators aim to study the way motivational process are recruited in schizophrenia.


Condition or disease Intervention/treatment Phase
Schizophrenia Other: realization of computerized exercises Not Applicable

Detailed Description:

behavioral protocol. Letters (vowel and consonant; upper- or lower- case) are presented in several colours into successive blocks. Each block included a series of eight letters. Each colour required a specific task given by a fixed rule (contextual control) but for some colour, the rule changes sometimes (episodic control). Participants are informed that payoffs vary according to their own performance. A frame indicates essay with bonus reward. Moreover a dashed frame indicates a low-bonus reward and a solid frame means a high-bonus reward. Thus different blocks are designed: low-incentive block and high incentive block.

This reward increased from standard to bonus motivation in high-incentive block (contextual motivation) and from low to high according to the type of blocks (episodic motivation) Reaction time may be higher in bonus reward Patients with schizophrenia are not sensitive to contextual motivation, and therefore patients should behave differently than control in contextual motivation.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 41 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Motivation and Executive Control in Schizophrenia
Actual Study Start Date : November 2012
Actual Primary Completion Date : April 24, 2018
Actual Study Completion Date : April 24, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Arm Intervention/treatment
Active Comparator: schizophrenia group
Schizophrenia patients suffering
Other: realization of computerized exercises
Sham Comparator: control group
subjects showing no psychological or neurological disorder
Other: realization of computerized exercises



Primary Outcome Measures :
  1. reaction time [ Time Frame: 24 hours ]
    reaction time is recorded when the subject press the key (subject should press a key function of the characteristics of the letter submitted)Reaction time should vary with the level of executive control (episodic, contextual, and motivation control (episodic or contextual motivation). Responses will be compared across patients and control.



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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 18-45 years old
  • schizophrenia
  • french native speaker

Exclusion Criteria:

  • Neurological disease
  • Motor or visual deficit
  • Somatic treatment with neurological impact
  • Drug abuse

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02734927


Locations
France
Professeur FRANCK Nicolas
Bron, Rhone-alpes, France, 69678
Sponsors and Collaborators
Hôpital le Vinatier

Responsible Party: Hôpital le Vinatier
ClinicalTrials.gov Identifier: NCT02734927     History of Changes
Other Study ID Numbers: 2012-A00026-37
First Posted: April 12, 2016    Key Record Dates
Last Update Posted: April 26, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Hôpital le Vinatier:
schizophrenia
motivation
executive control

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders