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Trial record 21 of 95 for:    body | Recruiting, Not yet recruiting, Available Studies | "Metabolic Syndrome X"

Chronic Inflammation and Exercise Responsiveness

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ClinicalTrials.gov Identifier: NCT02732509
Recruitment Status : Recruiting
First Posted : April 8, 2016
Last Update Posted : November 6, 2018
Sponsor:
Information provided by (Responsible Party):
Ian R. Lanza, Mayo Clinic

Brief Summary:
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.

Condition or disease
Metabolic Syndrome

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Study Type : Observational
Estimated Enrollment : 45 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Chronic Inflammation and Exercise Responsiveness
Study Start Date : March 2016
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine


Group/Cohort
Lean
Body mass index less than 25 kg/m2
Overweight/obese
Body mass index 25-45 kg/m2



Primary Outcome Measures :
  1. Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles [ Time Frame: 1 day ]


Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Men and women between the ages of 30-55 years will be recruited for this study. Fifteen individuals will be lean, defined as a body mass index (BMI) between 19 and 24 kg/m2. Thirty individuals will be overweight/obese, defined as a BMI between 25 and 45 kg/m2.
Criteria

Inclusion Criteria:

  • Age 30-55 years
  • BMI 19-45 kg/m2

Exclusion Criteria:

  • Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
  • Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
  • Renal insufficiency/failure (serum creatinine > 1.5mg/dl)
  • Oral warfarin group medications or history of blood clotting disorders.
  • Pregnancy or breastfeeding
  • Alcohol consumption greater than 2 glasses/day or other substance abuse
  • Untreated or uncontrolled thyroid disorders
  • Debilitating chronic disease (at the discretion of the investigators)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02732509


Contacts
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Contact: Ian R Lanza, PhD 507-255-8147 lanza.ian@Mayo.edu

Locations
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United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Ian R Lanza, PhD    507-255-8147    lanza.ian@mayo.edu   
Sponsors and Collaborators
Mayo Clinic
Investigators
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Principal Investigator: Ian R Lanza, PhD Mayo Clinic

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Responsible Party: Ian R. Lanza, Associate Professor of Medicine, Mayo Clinic
ClinicalTrials.gov Identifier: NCT02732509     History of Changes
Other Study ID Numbers: 16-000437
First Posted: April 8, 2016    Key Record Dates
Last Update Posted: November 6, 2018
Last Verified: November 2018

Additional relevant MeSH terms:
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Inflammation
Metabolic Syndrome
Pathologic Processes
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases