Diagnostic Performance of C Reactive Protein and Delta CRP in Acute Appendicitis (dCRPappend)
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|ClinicalTrials.gov Identifier: NCT02730585|
Recruitment Status : Completed
First Posted : April 6, 2016
Last Update Posted : September 1, 2016
|Condition or disease||Intervention/treatment|
|Appendicitis||Biological: C-reactive protein measurement|
Acute appendicitis is the most common surgical emergency and the most common source of community-acquired intra-abdominal infections. The lack of accuracy in the diagnosis of acute appendicitis yields often to two types of outcomes: a delay in diagnosis leads to perforation and peritonitis in up to 15% of the cases and unnecessary appendectomy is associated with post-operative complications such as wound infection and adhesions. CRP is an acute phase protein that is often used by many surgeons as a diagnostic marker of acute appendicitis. During the evaluation of patients with possible appendicitis in the emergency department (ED), repeated physical examination of the abdomen may provide further information about the decision making. However, the role of repeated laboratory examinations is not proven.
The purpose of this study was to investigate whether repeated serum CRP measures could be useful to predict acute appendicitis, after 3 hours of observation, in comparison with the histopathological findings.
|Study Type :||Observational|
|Actual Enrollment :||500 participants|
|Official Title:||Evaluation of the Performance of C-reactive Protein (CRP) Concentrations Variation (Delta CRP) in the Diagnosis of Acute Appendicitis in the ER|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||December 2013|
|Actual Study Completion Date :||December 2013|
all patients admitted to our hospital with a clinically suspected acute appendicitis.
Biological: C-reactive protein measurement
All patients included in this study underwent a blood sample analysis for C-reactive protein concentrations at admission and 3 hours later.
- Final diagnosis of acute appendicitis [ Time Frame: 15 days from patients inclusion ]The final diagnosis of acute appendicitis was based, in operated patients, on the results of the histologic examination of the excised appendix and, in non operated patients, on the absence of acute appendicitis at the 2 weeks follow-up visit.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02730585
|Emergency department of university hospital Fattouma Bourguiba of Monastir|
|Monastir, Tunisia, 5000|
|Principal Investigator:||Nouira Semir, Professor||University Hospital of Monastir|