Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia (DYSCHOL)
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|ClinicalTrials.gov Identifier: NCT02727361|
Recruitment Status : Completed
First Posted : April 4, 2016
Last Update Posted : February 25, 2019
|Condition or disease||Intervention/treatment||Phase|
|Dystonia||Radiation: PET (Positron Emission Tomography) imaging Other: MRI : Magnetic Resonance Imaging||Not Applicable|
The purpose of this study is to demonstrate that the phenotype of dystonia is associated with the degree of striatal ACh-I alterations.
In this molecular imaging study, the investigators will directly test this hypothesis using a PET radiotracer of the vesicular acetylcholine transporter (VAT). Their goal is to explore the relationships between cholinergic dysfunction and clinical disease expression and the associated morphological and functional alterations. The experimental protocol will also include multimodal MRI, MRI diffusion tensor (to study the microscopic structure of white matter) and functional MRI of the resting state (to study the functional organization of cerebral cholinergic networks at rest).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||March 1, 2018|
|Actual Study Completion Date :||March 1, 2018|
Experimental: Cholinergic striatal imaging
Cholinergic striatal imaging (IRM and TEP) to compare the intensity of the binding of cholinergic tracer
Radiation: PET (Positron Emission Tomography) imaging
Molecular imaging using a PET radiotracer of the vesicular acetylcholine transporter.
Other: MRI : Magnetic Resonance Imaging
Multimodal MRI, MRI diffusion tensor (to study the microscopic structure of white matter) and functional MRI of the resting state (to study the functional organization of cerebral cholinergic networks at rest).
- Binding potential [ Time Frame: Inclusion (V0) ]Image (PET) of the intensity of fixation of Cholinergic tracer (Binding potential)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02727361
|CHU de Bordeaux|
|Bordeaux, France, 33076|
|Principal Investigator:||FERNANDEZ Philippe||CHU Bordeaux|
|Study Chair:||BURBAUD Pierre||Université de Bordeaux|