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Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease

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ClinicalTrials.gov Identifier: NCT02720861
Recruitment Status : Unknown
Verified March 2016 by Suporn Travanichakul, MD., Chulalongkorn University.
Recruitment status was:  Recruiting
First Posted : March 28, 2016
Last Update Posted : March 28, 2016
Sponsor:
Information provided by (Responsible Party):
Suporn Travanichakul, MD., Chulalongkorn University

Study Description
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Brief Summary:
To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.

Condition or disease Intervention/treatment
Ischemic Stroke Genetic: DNA sequencing

Detailed Description:
This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.
Study Design
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Study Type : Observational [Patient Registry]
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Year
Official Title: Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease: A Cross-sectional Study in Thai Patients
Study Start Date : March 2015
Actual Primary Completion Date : March 2016
Estimated Study Completion Date : June 2016

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Groups and Cohorts
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Group/Cohort Intervention/treatment
non embolic ischemic stroke
acute ischemic stroke from atherosclerosis or lacunar stroke
 Genetic: DNA sequencing
withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene


Outcome Measures
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Primary Outcome Measures :
  1. Number of Participants With RNF213 rs112735431 Gene polymorphism [ Time Frame: 1 year ]

Biospecimen Retention:   Samples With DNA
Blood sample.

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Acute ischemic stroke patients of Chulalongkorn hospital
Criteria

Inclusion Criteria:

  • Nationality in Thailand
  • Age equal or more than 18 years
  • Clinical and imaging diagnosis of acute ischemic stroke
  • Patient consent to participate in the research

Exclusion Criteria:

  • High risk for cardioembolic stroke by TOAST classification
  • Contraindication for venipuncture
  • Pregnancy or breast feeding patient
  • History of head and neck radiation
  • Down's syndrome
  • Marfan syndrome
  • Autoimmune disease such as SLE
  • Ongoing malignancy or remission of malignancy less than 1year
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02720861


Contacts
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Contact: Suporn Travanichakul, MD 0858054513 stravanichakul@yahoo.com

Locations
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Thailand
Suporn Travanichakul Recruiting
Bangkok, Thailand, 10330
Contact: Suporn Travanichakul, MD    0858054513    stravanichakul@yahoo.com   
Principal Investigator: Aurauma Chutinet, MD         
Principal Investigator: Nijasri Charnnarong, MD         
Principal Investigator: Thiti Snabboon, MD         
Sponsors and Collaborators
Chulalongkorn University
Investigators
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Principal Investigator: Suporn Travanichakul, MD Chulalongkorn University
More Information
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Additional Information:

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Responsible Party: Suporn Travanichakul, MD., Neurology Division of Chulalongkorn hospital, Chulalongkorn University
ClinicalTrials.gov Identifier: NCT02720861    
Other Study ID Numbers: COA No.282/2015
First Posted: March 28, 2016    Key Record Dates
Last Update Posted: March 28, 2016
Last Verified: March 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: Not Share
Keywords provided by Suporn Travanichakul, MD., Chulalongkorn University:
RNF213 rs112735431 Gene
Acute Non-embolic ischemic stroke
Additional relevant MeSH terms:
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Cerebrovascular Disorders
Ischemia
Brain Diseases
Central Nervous System Diseases
 Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Pathologic Processes