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Extended Treatment Access Study of MT-3724 for Subjects With Relapsed Non-Hodgkin's B-Cell Lymphoma

Expanded access is currently available for this treatment.
Verified March 2016 by Molecular Templates, Inc.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02715843
First Posted: March 22, 2016
Last Update Posted: March 22, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Molecular Templates, Inc.
  Purpose
This is an active treatment, extended access study open solely to those subjects who have successfully completed the Core and Repeat Dosing portions of the MT-3724_NHL_001_US clinical study and who, in the investigator's judgment, (i) have not had progressive disease while on MT-3724 treatment (i.e.; have shown a complete or partial response or stable disease), (ii) have experienced no clinical or laboratory toxicities that would contraindicate further MT-3724 dosing and (iii) have no acceptable and better alternative treatment available to them.

Condition Intervention
Non-Hodgkin's B-cell Lymphoma Drug: MT-3724

Study Type: Expanded Access     What is Expanded Access?
Official Title: Extended Treatment Access Study of MT-3724 for Subjects With Relapsed Non-Hodgkin's B-Cell Lymphoma Who Have Completed Phase I/Ib Study MT-3724_NHL_001_US

Resource links provided by NLM:


Further study details as provided by Molecular Templates, Inc.:

Study Start Date: December 2015
Estimated Study Completion Date: January 2018
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: MT-3724
    Intravenous dosing M-W-F X 2 weeks; MT-3724 infusion over 2 hours on each dosing day over 4 week initial cycle and then 3 week repeat cycles for up to 5 total cycles.
Detailed Description:

Each treatment cycle will consist of 6 doses of MT-3724 to be administered over 12 days followed by at least 9 days of observation but longer intervals between dosing cycles will be allowed at the investigator's discretion (e.g., 6 doses of MT-2734 over 12 days followed by 16 days observation). Subjects in this extension study may continue to receive up to 6 additional cycles in the absence of clear disease progression or toxicity. If a subject achieves complete remission, two additional cycles will be attempted, after which dosing may be suspended prior to completion of the maximum 6 cycles.

In accordance with CFR Title 21, Part 312.315, Subpart I (Expanded Access to Investigational Drugs for Treatment Use for Intermediate-size Populations) this study will be submitted to the MT-2724 IND (# 121918) for FDA review and approval. Prior to enrolling a subject in this study each investigator who elects to participate in this study is responsible to (i) obtain local institutional review board (IRB) approval for this study and its associated informed consent form, (ii) review each potential study candidate's eligibility with the sponsor and (iii) obtain each potential subject's signed, local IRB approved informed consent form for this study prior to performing any study related activities.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Eligible subjects must be adequately informed of all study procedures and fully consent to participation as demonstrated by signing the Informed Consent Form (ICF).
  • Eligible subjects must require treatment for their NHL and have:

    • tolerated MT-3724 throughout the MT-3724_NHL_001_US Phase I/Ib study (Core and Repeat Dosing),
    • successfully completed the Core and Repeat Dosing portions of MT-3724_NHL_001_US Phase I/Ib study as defined by that protocol,
    • received no other treatment for their NHL since enrollment in the MT-3724_NHL_001_US Phase I/Ib study,
    • maintained stable disease or better throughout that study and
    • been assessed by the investigator to have no other acceptable and better treatment options available to them. The investigator must document in the potential subject's medical record that there are no other approved treatment options available and/or appropriate for the potential subject or that the potential subject has declined any other approved treatment options that me be available to them.
  • Potential subjects must continue to meet the diagnostic criteria for B-Cell NHL that allowed them to be eligible for the MT-3724_NHL_001_US Phase I/Ib study.
  • Potential subjects must have received all approved therapies known to provide clinical benefit for their disease subtype and for which they are eligible or must have refused these treatment options prior to consideration for continued compassionate use treatment with MT-3724 through enrollment in this protocol. In the case of subjects who have lymphomas for which high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT) is considered a standard curative therapy, eligibility for MT-3724 compassionate use requires that the subject's disease relapsed after HD-ASCT, that the subject is not eligible for HD ASCT, or that the subject has refused HD-ASCT.
  • Potential subjects with known central nervous system (CNS) metastases may be enrolled if they:

    • have previously been treated with radiotherapy for their CNS disease,
    • do not require chronic steroid therapy,
    • have had computed tomography or magnetic resonance imaging of the brain within 1 month of this study's entry that showed stable disease and
    • have no neurological symptoms (excluding Grade 1 or 2 neuropathy).
  • Eastern Cooperative Oncology Group (ECOG) performance status of < 3
  • Potential subjects should have measurable disease (any tumor mass of at least 1.5 cm) which has been documented to not have progressed during the MT-3724_NHL_001_US Phase I/Ib study and which can be followed during extended treatment for possible new disease progression.
  • Potential subjects must be at least 9 days past their last course of MT-3724 treatment and have recovered from any side effects attributed to MT-3724 to at least Common Terminology Criteria for Adverse Events (CTCAE, v. 4.03; Appendix 4) Grade 2 prior to initiating additional cycles of MT-3724 through this compassionate use protocol. Subjects with pre-existing AEs at screening that are severe or life threatening by CTCAE grading should not be enrolled.
  • Laboratory requirements:

    • Absolute neutrophil count (ANC) > 1,000 per microliter (μL)
    • Platelet count > 25,000/μL (The potential subject must be asymptomatic and the thrombocytopenia must be secondary to bone marrow infiltration by tumor and not secondary to increased platelet consumption or the effect of previous marrow suppressing treatment or infection.)
    • Hemoglobin ≥ 8.0 g/dL
    • Total bilirubin < 1.5 times upper limit of normal (ULN) (unless due to Gilbert's Disease)
    • Aspartate aminotransferase (AST; SGOT) and alanine aminotransferase (ALT; SGPT) < 2.5 times ULN or < 5x ULN if liver metastases are present
    • Serum creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 50 ml/min (either measured or estimated by the Cockcroft-Gault formula).
  • Females of childbearing potential must have a negative serum or urine pregnancy test within 3 days prior to initiating dosing. Male and female subjects with reproductive potential must agree to use appropriate contraceptive methods while on study therapy and for 84 days following their last dose of study medication.

Exclusion Criteria:

  • Patients who cannot comply with protocol requirements including clinic visits for intravenous infusions and birth control measures may not be enrolled.
  • Female patients who are pregnant or are breast feeding.
  • Potential patients with a history of another cancer other than basal cell carcinoma or cervical intraepithelial neoplasia (cervical cancer in situ) may not be enrolled unless it is documented that their previous cancer was treated, they have been disease free for five or more years prior to starting this study and they are in their doctor's judgment at less than 30% risk of relapse of this previous malignancy.
  • Patients with a peripheral blood total lymphocyte count of higher than 25,000/mm3 may not be enrolled.
  • Patients cannot have experienced a significant (CTCAE Grade 3 or 4 with or without neutropenia) infection within 2 weeks of their first dose of MT-3724.
  • Patients are not eligible if they are using any other approved or investigational anti-neoplastic therapies or any other investigational therapies for any other reason.
  • Patients may not be receiving systemic corticosteroid therapy at a prednisone dose > 20 mg/day (or steroid equivalent) within 2 weeks of starting study.
  • Patients with uncontrolled or severe cardiovascular disease, including myocardial infarct or unstable angina within 6 months prior to start of study treatment, New York Heart Association (NYHA) Class II or greater congestive heart failure, serious arrhythmias requiring medication for treatment, clinically significant pericardial disease, or cardiac amyloidosis may not be enrolled.
  • Patients with a known history of drug abuse or any chronic neurologic, psychiatric, endocrine, metabolic, immunologic, hepatic or renal disease (including a history of hemolytic uremic syndrome) that in the opinion of the Investigator would adversely affect study participation.
  • Patients with known active Hepatitis C, HIV or a present history of Hepatitis B
  • Patients must not have received any vaccines for 28 days prior to administration of their first dose of MT-3724 and should not receive any vaccine during the study or within 28 days after their last dose of MT-3724.
  • Patients with a suspected allergy or sensitivity to any component of MT-3724 drug preparation based upon known allergies to compounds of a similar class who have had an anaphylactic or other severe infusion reaction to human immunoglobulin or monoclonal antibody administration are n ot eligible.
  • Patients who have had an allogeneic hematopoietic stem cell transplantation are not eligible.
  • Patients who have had major surgery within 6 weeks prior to the first dose of study drug or have major surgery planned during the first 12 weeks after MT-3724 has finished.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02715843


Contacts
Contact: David Valacer, MD david.valacer@moleculartemplates.com
Contact: Allen Moton, PharmD allen.moton@moleculartemplates.com

Locations
United States, Arizona
University of Arizona
Tuscon, Arizona, United States, 85724
Contact: Daniel Persky, MD         
Contact: Diane Rensvold    520-684-9055    drensvold@uacc.arizona.edu   
United States, New York
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Contact: Paul Hamlin, MD         
New York University Langone Medical Center
New York, New York, United States
Contact: Catherine Diefenbach, MD         
United States, North Carolina
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Contact: Steven Park, MD    919-843-5968    steven_park@med.unc.edu   
Contact: Barbara Riff    984-974-8660    barbara_riff@med.unc.edu   
United States, Texas
MD Anderson Cancer Center
Houston, Texas, United States
Contact: Michelle Fanale, MD         
Sponsors and Collaborators
Molecular Templates, Inc.
  More Information

Responsible Party: Molecular Templates, Inc.
ClinicalTrials.gov Identifier: NCT02715843     History of Changes
Other Study ID Numbers: MT-3724_NHL_001_EXT_US
First Submitted: February 23, 2016
First Posted: March 22, 2016
Last Update Posted: March 22, 2016
Last Verified: March 2016

Keywords provided by Molecular Templates, Inc.:
CD20
immunotoxin
NHL
non-Hodgkin's lymphoma
lymphoma
cancer
antibodies
immunotherapy
safety
pharmacokinetics
MT-3724
relapsed
refractory

Additional relevant MeSH terms:
Lymphoma
Lymphoma, B-Cell
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Lymphoma, Non-Hodgkin