Effect of Plasma Rich in Growth Factors on Semen Quality
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|ClinicalTrials.gov Identifier: NCT02708537|
Recruitment Status : Completed
First Posted : March 15, 2016
Last Update Posted : August 1, 2022
|Condition or disease||Intervention/treatment|
|Vascular Endothelial Growth Factor Overexpression||Biological: PRGF in candidates for sperm donors|
Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.
One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Effect of Plasma Rich in Growth Factors (PRGF) on Semen Quality|
|Actual Study Start Date :||April 2016|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||December 2017|
PRGF in candidates for sperm donors
Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.
Biological: PRGF in candidates for sperm donors
PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.
- Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added [ Time Frame: 6 months ]
Within concerted donor visits in IVI Bilbao will be held:
- Removing Blood 9 mL of blood to obtain plasma rich in factors growth
- Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility.
- Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02708537
|Leioa, Vizcaya, Spain, 48011|
|Leioa, Vizcaya, Spain, 48940|
|Study Director:||Marcos Ferrando||IVI Bilbao|