Molecular Mechanisms of Antipsychotic-induced Insulin Resistance
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This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.
Condition or disease
Adverse Effect of Other Antipsychotics and NeurolepticsInsulin Resistance
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Ages Eligible for Study:
21 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
We will include persons that meet the following criteria:
21-45 years old
No history of drug or alcohol dependence or abuse
No current or past history of psychiatric or neurologic disease
minimal exercise routine prior or during study (light walking allowed)
Normal liver function tests and 7) minimal alcohol intake (<1 drink per day).
The following persons will be excluded:
Has 1st degree relative with diabetes (I or II)
current or re-cent nicotine intake
presence of organic/physical disease that could affect glucose
currently taking prescription or over-the-counter medications that could affect glucose
currently pregnant or lactating
unwilling to take acceptable birth control method
current or previous exposure to antipsychotics
history of unstable weight
personal or family history of cardiac arrhythmias or seizures
current or past history of eating disorder(s) or restricted diet
allergy to lidocaine or drug excipients
history of difficulty with intravenous line placement