Quality of Pediatric Resuscitation in a Multicenter Collaborative (pediRES-Q)
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|ClinicalTrials.gov Identifier: NCT02708134|
Recruitment Status : Recruiting
First Posted : March 15, 2016
Last Update Posted : March 25, 2021
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.
The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
|Condition or disease|
|Cardiac Arrest Cardiopulmonary Arrest|
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
|Study Type :||Observational|
|Estimated Enrollment :||5000 participants|
|Official Title:||Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study|
|Study Start Date :||March 2016|
|Estimated Primary Completion Date :||January 2025|
|Estimated Study Completion Date :||January 2026|
Pediatric Cardiac Arrests
Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations.
- Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR [ Time Frame: 10 Years ]Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02708134
|Contact: Vinay Nadkarni, MD, MSemail@example.com|
|Contact: Dana Nilesfirstname.lastname@example.org|
|United States, California|
|Palo Alto, California, United States, 94304|
|Contact: Felice Su|
|United States, Illinois|
|University of Chicago, Comer Children's Hospital||Recruiting|
|Chicago, Illinois, United States, 60637|
|Contact: Priti Jani|
|United States, Ohio|
|Cincinnati Children's Hospital Medical Center||Recruiting|
|Cincinnati, Ohio, United States|
|Contact: Maya Dewan|
|Nationwide Children's Hospital||Recruiting|
|Columbus, Ohio, United States|
|Contact: Tensing Maa|
|United States, Pennsylvania|
|Children's Hospital of Philadelphia||Recruiting|
|Philadelphia, Pennsylvania, United States, 19104|
|Contact: Vinay Nadkarni, MD, MS 215-590-7430 email@example.com|
|United States, Washington|
|Seattle Children's Hospital||Recruiting|
|Seattle, Washington, United States, 98105|
|Contact: Joan Roberts|
|Principal Investigator:||Vinay Nadkarni, MD, MS||Children's Hospital of Philadelphia|