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Committed Actions for Successful Aging (CASA)

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ClinicalTrials.gov Identifier: NCT02702570
Recruitment Status : Recruiting
First Posted : March 8, 2016
Last Update Posted : March 5, 2019
Sponsor:
Information provided by (Responsible Party):
Yonas E Geda, Mayo Clinic

Brief Summary:
The investigators are planning to recruit approximately 30 study participants aged 50 years and older that will undergo a 4 week attention and emotion regulation intervention. The intervention systematically targets thoughts, emotions and behavior in order to promote quality of life and advance successful brain aging. The investigators will assess the feasibility of recruiting and retaining participants for an attention and emotion regulation intervention. In addition, the investigators will determine the efficacy of the intervention to enhance and promote quality of life, sustained attention, emotions, motivation and cognitive health.

Condition or disease Intervention/treatment Phase
Brain Aging Behavioral: CASA Not Applicable

Detailed Description:
The CASA model is developed here in the investigators program (Geda et al) based on neuroscience and Acceptance and Commitment Therapy (ACT). The rationale for the study is that the cortico-cortical network linking the prefrontal cortex with the mesial temporal lobe is susceptible to the wear and tear of day to day life such as stress and emotional distress. The investigators hypothesize that the CASA intervention will promote emotional and cognitive health by targeting this network.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Committed Actions for Successful Aging
Study Start Date : May 2016
Estimated Primary Completion Date : January 2020
Estimated Study Completion Date : May 2020

Arm Intervention/treatment
CASA intervention
Each participant serves as his/her own control. Measures administered before and after an intervention.
Behavioral: CASA
Each participant serves as his/her own control. Measures administered before and after the behavioral intervention.




Primary Outcome Measures :
  1. WHOQOL-BREF quality of life questionnaire [ Time Frame: Baseline, one year ]
    The WHOQOL-BREF instrument comprises 26 items, which measure the following broad domains: physical health, psychological health, social relationships, and environment. The WHOQOL-BREF is a shorter version of the original instrument that may be more convenient for use in large research studies or clinical trials. Scoring is 1-5 with 1 being either - Not at all, Very poor, Very dissatisfied, or Never. 2 being either - Not much, Poor, Dissatisfied, A little, or Seldom. 3 being either - Moderately, Neither poor nor good, Neither satisfied nor dissatisfied, A moderated amount, or Quite often. 4 being either - A great deal, Good, Satisfied, Very much, Mostly, Good, or Very often. 5 being either - Completely, Very good, Very satisfied, An extreme amount, Extremely, or Always.


Secondary Outcome Measures :
  1. Perceived Stress Scale [ Time Frame: Baseline, one year ]
    The Perceived Stress Scale (PSS) is the most widely used psychological instrument for measuring the perception of stress. It is a measure of the degree to which situations in one's life are appraised as stressful. The scale also includes a number of direct queries about current levels of experienced stress. The PSS was designed for use in community samples with at least a junior high school education. The questions are of a general nature and hence are relatively free of content specific to any subpopulation group. The questions in the PSS ask about feelings and thoughts during the last month. In each case, respondents are asked how often they felt a certain way. PSS scores are obtained by reversing responses (e.g., 0 = 4, 1 = 3, 2 = 2, 3 = 1 & 4 = 0) to the four positively stated items (items 4, 5, 7, & 8) and then summing across all scale items. A short 4 item scale can be made from questions 2, 4, 5 and 10 of the PSS 10 item scale.



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Ages Eligible for Study:   50 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Participants will be recruited from the community via advertisement in retirement communities, church, and other social gatherings. Eligible participants are cognitively normal males and females aged 50 years and older.

Inclusion criteria:

  • Subject will sign approved consent form
  • Male or female adults (age > 50 years of age)
  • Subject will complete all of the testing and procedures

Exclusion criteria:

  • Refusal to sign the approved consent form
  • Refusal to complete all testing and procedures of the study
  • Males and females < age of 50 years

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02702570


Contacts
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Contact: Charlene D Robinson, BSc 480-301-8000 robinson.charlene1@mayo.edu

Locations
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United States, Arizona
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Sponsors and Collaborators
Mayo Clinic
Investigators
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Principal Investigator: Yonas E Geda, MD Mayo Clinic

Additional Information:
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Responsible Party: Yonas E Geda, Professor, Mayo Clinic
ClinicalTrials.gov Identifier: NCT02702570     History of Changes
Other Study ID Numbers: 14-008490
First Posted: March 8, 2016    Key Record Dates
Last Update Posted: March 5, 2019
Last Verified: March 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided