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Lymphocyte Count as a Sign of Immunoparalysis and Its Correlation With Nutritional Status in Septic Pediatric Patients

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ClinicalTrials.gov Identifier: NCT02698683
Recruitment Status : Completed
First Posted : March 4, 2016
Last Update Posted : March 4, 2016
Sponsor:
Information provided by (Responsible Party):
Talita Freitas Manzoli, University of Sao Paulo

Brief Summary:
Participants were classified as normal or malnourished according to anthropometric measures. Serum albumin and zinc were recovered on the 1st and 7th days of hospitalization. Lymphocyte count was also recorded on the 1st and 7th days.

Condition or disease Intervention/treatment
Lymphopenia Other: lymphocyte count

Detailed Description:
The investigators enrolled 14 consecutive patients with sepsis. Patients were classified as normal or malnourished according to anthropometric measures. As an additional evaluation of nutritional status, serum albumin and zinc were recovered on the 1st and 7th days of hospitalization. Lymphocyte count was also recorded on the 1st and 7th days. Investigators correlated nutritional status with lymphocyte count and zinc dosage.

Study Type : Observational
Actual Enrollment : 14 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Lymphocyte Count as a Sign of Immunoparalysis and Its Correlation With Nutritional Status in Septic Pediatric Intensive Care Patients: A Pilot Study
Study Start Date : February 2014
Actual Primary Completion Date : June 2015
Actual Study Completion Date : January 2016

Group/Cohort Intervention/treatment
malnourished
low zinc, low albumin, anthropometric measures lower than percentile 5 lymphocyte count
Other: lymphocyte count
lymphocyte count

well nourished
normal zinc, normal albumin, anthropometric measures higher than percentile 5 lymphocyte count
Other: lymphocyte count
lymphocyte count




Primary Outcome Measures :
  1. presence of lymphopenia [ Time Frame: seven days ]


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Ages Eligible for Study:   1 Month to 14 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
pediatric septic patients
Criteria

Inclusion Criteria:

  • septic patients

Exclusion Criteria:


Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Talita Freitas Manzoli, Medical doctor, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT02698683     History of Changes
Other Study ID Numbers: 2015-LCSINS
First Posted: March 4, 2016    Key Record Dates
Last Update Posted: March 4, 2016
Last Verified: February 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: there is no plan to share data

Keywords provided by Talita Freitas Manzoli, University of Sao Paulo:
Nutrition
Lymphocyte Count
Immunoparalysis
nutritional status of septic patients

Additional relevant MeSH terms:
Lymphopenia
Leukopenia
Leukocyte Disorders
Hematologic Diseases
Immunologic Deficiency Syndromes
Immune System Diseases