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MRI Perfusion in Adnexal Masses (MRI-CAM)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02694406
Recruitment Status : Completed
First Posted : February 29, 2016
Last Update Posted : June 27, 2018
Sponsor:
Information provided by (Responsible Party):
Ahmed Mohamed Abbas, Assiut University

Brief Summary:

As ovarian cancer is characterized by an anarchic neovascularization resulting in a wide number of immature microvessels. These vessels are characterized by a lack of coverage by pericytes and the higher expression of one of the receptors of Vascular Endothelial Growth Factor on both endothelial and epithelial cells of ovarian cystadenocarcinomas. These physio pathogenic characteristics have been demonstrated to be in line with variations of MR perfusion parameters.

Unlike many lesions that occur in other parts of the body, biopsy should not be performed in adnexal masses that demonstrate no evidence of peritoneal disease because it may cause spillage of cystic contents, potentially leading to iatrogenic up-staging of what may have been a malignant tumor that was limited.


Condition or disease Intervention/treatment
Complex Adnexal Masses Device: MRI perfusion

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Study Type : Observational
Actual Enrollment : 40 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Added Value of MRI Perfusion in Evaluation of Complex Adnexal Masses
Actual Study Start Date : July 2015
Actual Primary Completion Date : November 1, 2017
Actual Study Completion Date : December 1, 2017

Intervention Details:
  • Device: MRI perfusion
    contrast-enhanced MR imaging including perfusion weighted imaging (PWI)


Primary Outcome Measures :
  1. detect the number of malignant adnexal masses [ Time Frame: 2 weeks ]


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with adenxal masses
Criteria

Inclusion Criteria:

  • complex adnexal mass
  • patient fit for surgery

Exclusion Criteria:

  • any general contraindication to MRI
  • severely ill patients
  • those with claustrophobia.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02694406


Locations
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Egypt
Ahmed Abbas
Assiut, Cairo, Egypt, 002
Ahmed Abbas
Assiut, Egypt
Sponsors and Collaborators
Assiut University

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Responsible Party: Ahmed Mohamed Abbas, Dr, Assiut University
ClinicalTrials.gov Identifier: NCT02694406     History of Changes
Other Study ID Numbers: MRI-CAM
First Posted: February 29, 2016    Key Record Dates
Last Update Posted: June 27, 2018
Last Verified: June 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Keywords provided by Ahmed Mohamed Abbas, Assiut University:
Diagnosis