Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis
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ClinicalTrials.gov Identifier: NCT02686853
Recruitment Status : Unknown
Verified February 2016 by Hui Bu, Hebei Medical University. Recruitment status was: Not yet recruiting
The main purpose of this study is to observe the clinical effect of intrathecal administration of liposomal amphotericin B in Cryptococcal Meningitis without Acquired Immune Deficiency Syndrome (AIDS).
laboratory examination of cerebrospinal fluid [ Time Frame: 2 to 4 weeks ]
It includes routine test，biochemistry indicators and cytology ，namely white blood cell count per litre， protein（in g/l），glucose（in mmol/l）and chloride（in mmol/l）in cerebrospinal fluid ，an assessment will be assessed every week
Secondary Outcome Measures :
changes of clinical symptoms [ Time Frame: 2 to 4 weeks ]
headache duration, duration of fever,presence of cranial nerve damage
Other Outcome Measures:
The incidence of adverse reactions [ Time Frame: 24 hours ]
Lower back pain，lower extremity weakness， paraplegia，sphincter disturbance.
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Ages Eligible for Study:
14 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Cryptococcus neoformans are found in CSF
Patients with serious heart, lung, liver and renal insufficiency.
Patients who took broad-spectrum antibiotics and corticosteroids for a long-term.
Patients with AIDS or obvious immunodeficiency.
Patients with long term dialysis or intravenous catheter.
Patients with other brain organic disease such as purulent meningitis, intracranial swelling, etc.
Keywords provided by Hui Bu, Hebei Medical University:
Liposomal amphotericin B
Without Acquired Immune Deficiency Syndrome
Additional relevant MeSH terms:
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Acquired Immunodeficiency Syndrome
Central Nervous System Diseases
Nervous System Diseases
Central Nervous System Fungal Infections
Central Nervous System Infections
RNA Virus Infections