Meniscal Tear and Osteoarthritis Risk (MenTOR) (MenTOR)
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Adults with degenerative meniscal tear receiving arthroscopic surgical management or knee drainage (arthrocentesis) +/- intra-articular steroid injection will be recruited to this non-interventional cohort study. The aim is to investigate whether measurement of an individual's synovial fluid biomarker response to a degenerative meniscal tear with symptoms predicts symptomatic and functional outcome suggestive of osteoarthritis (OA) of the knee.
Knee Injury and Osteoarthritis Outcomes Score (KOOS)-4 [ Time Frame: 2 years ]
summary score from validated KOOS questionnaire. To investigate whether measurement of an individual's synovial fluid biomarker response to a degenerative meniscal tear with symptoms predicts symptomatic and functional outcome suggestive of OA of the knee.
Secondary Outcome Measures :
X ray Kellgren Lawrence (KL) change [ Time Frame: 2 years ]
X ray of knee.Change in KL grade over time will be measured.
MRI semi-quantitative score [ Time Frame: 2 years ]
MRI knee. Change in semi-quantitative score over time will be measured.
Oxford Knee Score - Activity and Participation Questionnaire (OKS-APQ) [ Time Frame: 2 years ]
The OKS-APQ will be used to document pain and symptoms, and compared with KOOS.
Biospecimen Retention: Samples With DNA
Blood samples (plasma, serum, DNA where consent is given), urine, synovial fluid (where an appropriate clinically indicated procedure has been carried out to allow access).
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Layout table for eligibility information
Ages Eligible for Study:
30 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with a confirmed meniscal tear, likely degenerative in nature, will be invited to participate in the MenTOR study. Male and female adults with a MRI-evident meniscal tear and evidence of no/minor osteoarthritic change (KL grade 2 or less) who are undergoing arthroscopic treatment, or planned arthrocentesis/injection will be identified in clinics all located at the Nuffield Orthopaedic Centre (NOC). The primary source of recruitment is anticipated to be the secondary care orthopaedic knee service. The patient's symptoms will be such that they warrant further management.
Male or female aged 30-60 years.
Participant able and willing to give informed consent.
Clinical assessment demonstrates mechanical symptoms suggestive of meniscal pathology (focal knee pain +/- 1 or more of: catching/locking, giving way, focal joint-line tenderness, effusion, McMurray's positive) within last 12 months.
Evidence on clinical MRI knee of meniscal tear.
Participant is either in secondary care or has the potential to be referred to secondary care due to severity of symptoms.
Patient has failed conservative therapy and elected for surgical arthroscopic treatment, or is due knee drainage/injection for clinical reasons.
Competency of the English language to complete questionnaires independently.
Pre-existing advanced radiographic OA (KL grade 3-4) of index knee at baseline.
Evidence of anterior cruciate ligament rupture, or more extensive soft tissue injury.
History of an acute knee injury (within 12 weeks), or acutely locked knee
Known history of inflammatory/septic arthritis of index knee.
Knee replacement or other non-arthroscopic knee surgery (e.g. high tibial osteotomy) - previous or planned within 1 year of study start.
Index knee surgery within last 3 months, including meniscectomy.
Steroid injection to index knee in last 3 months.
Active other (treated) inflammatory disease or infection.