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Multi-center Imaging Genetics Studies in China (CHIMGEN)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02681822
Recruitment Status : Recruiting
First Posted : February 12, 2016
Last Update Posted : April 10, 2019
Sponsor:
Collaborators:
Tianjin Medical University Cancer Institute and Hospital
Tianjin Medical University Second Hospital
Tianjin First Central Hospital
Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces
School of Medical Imaging, Tianjin Medical University
Tianjin Huanhu Hospital
Beijing Hospital
Chinese PLA General Hospital
Beijing Tongren Hospital
Xuanwu Hospital, Beijing
Peking Union Medical College Hospital
Beijing Normal University
Chinese Academy of Science Institute of Automation
The Second Hospital of Hebei Medical University
The First Affiliated Hospital of Shanxi Medical University
Inner Mongolia Medical College Hospital
First Hospital of Jilin University
The Frist Hospital Of China Medical University
The First Affiliated Hospital of Dalian Medical University
RenJi Hospital
Huashan Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing PLA General Hospital
The First Affiliated Hospital with Nanjing Medical University
Xuzhou Medical University
Second Affiliated Hospital, School of Medicine, Zhejiang University
First Affiliated Hospital of Wenzhou Medical University
The First Affiliated Hospital of Anhui Medical University
Shan dong Medical Imaging Research Institute
Qilu Hospital of Shandong University
Yantai Yuhuangding Hospital
Henan Provincial Hospital
The First Affiliated Hospital of Zhengzhou University
Tongji Hospital
Wuhan University
Xiangya Hospital of Central South University
Central South University
Guangdong Provincial People's Hospital
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
South China Normal University、Hainan General Hospital
First Affiliated Hospital Xi'an Jiaotong University
Xijing Hospital
Tang-Du Hospital
LanZhou University
West China Hospital
Second Affiliated Hospital of Wenzhou Medical University
University of Electronic Science and Technology of China
First Affiliated Hospital of Chongqing Medical University
Southwest Hospital, China
The University of Science and Technology of China
Guangdong No.2 Provincial People's Hospital
Information provided by (Responsible Party):
Chunshui Yu, Tianjin Medical University General Hospital

Brief Summary:
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.

Condition or disease
Alzheimer Disease Schizophrenia Major Depressive Disorders

Detailed Description:
The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.

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Study Type : Observational
Estimated Enrollment : 10000 participants
Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Multi-center Imaging Genetics Studies in China
Study Start Date : November 2015
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2020


Group/Cohort
Healthy young subjects
Healthy young Chinese Han subjects aged 18-30



Primary Outcome Measures :
  1. Brain structure and function measured by MRI scans [ Time Frame: 2 years ]
    The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.


Secondary Outcome Measures :
  1. Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version) [ Time Frame: 2 years ]
    To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism.


Biospecimen Retention:   Samples With DNA
The investigators retain the peripheral blood drawn from antecubital vein in order to acquire the genotype, whether the healthy young participants carry the risk allele of one specific gene or not. No matter what genotypes the participants own, no specific intervention measure will be done among the participants.


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy young Chinese Han subjects age 18-30
Criteria

Inclusion Criteria:

  • aged 18-30
  • Chinese Han
  • right-handed
  • without history of neuropsychiatric disease
  • no substance addiction
  • smoking

Exclusion Criteria:

  • younger or elder than 18-30 year-old
  • other ethnics
  • with history of neuropsychiatric disease
  • with history of neuropsychiatric disease among first,second and third degree relatives

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02681822


Contacts
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Contact: Chunshui Yu, PhD chunshuiyu@vip.163.com
Contact: Qiang Xu, PhD xuqiang9042@gmail.com

Locations
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China, Tianjin
Tianjin Medical University General Hospital Recruiting
Tianjin, Tianjin, China, 300052
Contact: Chunshui Yu, PhD       chunshuiyu@vip.163.com   
Contact: Qiang Xu, PhD       xuqiang9042@gmail.com   
Sponsors and Collaborators
Tianjin Medical University General Hospital
Tianjin Medical University Cancer Institute and Hospital
Tianjin Medical University Second Hospital
Tianjin First Central Hospital
Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces
School of Medical Imaging, Tianjin Medical University
Tianjin Huanhu Hospital
Beijing Hospital
Chinese PLA General Hospital
Beijing Tongren Hospital
Xuanwu Hospital, Beijing
Peking Union Medical College Hospital
Beijing Normal University
Chinese Academy of Science Institute of Automation
The Second Hospital of Hebei Medical University
The First Affiliated Hospital of Shanxi Medical University
Inner Mongolia Medical College Hospital
First Hospital of Jilin University
The Frist Hospital Of China Medical University
The First Affiliated Hospital of Dalian Medical University
RenJi Hospital
Huashan Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing PLA General Hospital
The First Affiliated Hospital with Nanjing Medical University
Xuzhou Medical University
Second Affiliated Hospital, School of Medicine, Zhejiang University
First Affiliated Hospital of Wenzhou Medical University
The First Affiliated Hospital of Anhui Medical University
Shan dong Medical Imaging Research Institute
Qilu Hospital of Shandong University
Yantai Yuhuangding Hospital
Henan Provincial Hospital
The First Affiliated Hospital of Zhengzhou University
Tongji Hospital
Wuhan University
Xiangya Hospital of Central South University
Central South University
Guangdong Provincial People's Hospital
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
South China Normal University、Hainan General Hospital
First Affiliated Hospital Xi'an Jiaotong University
Xijing Hospital
Tang-Du Hospital
LanZhou University
West China Hospital
Second Affiliated Hospital of Wenzhou Medical University
University of Electronic Science and Technology of China
First Affiliated Hospital of Chongqing Medical University
Southwest Hospital, China
The University of Science and Technology of China
Guangdong No.2 Provincial People's Hospital
Investigators
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Principal Investigator: Chunshui Yu, PhD Tianjin Medical University General Hospital

Publications:
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Responsible Party: Chunshui Yu, Head of Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital
ClinicalTrials.gov Identifier: NCT02681822    
Other Study ID Numbers: 81425013
First Posted: February 12, 2016    Key Record Dates
Last Update Posted: April 10, 2019
Last Verified: April 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: The investigators plan to share the IPD with the member institutes or hospitals after the total completion of the investigation.
Keywords provided by Chunshui Yu, Tianjin Medical University General Hospital:
Genome-wide association studies
Environmental factors
Behavioral Assessment
Pathway analysis
Additional relevant MeSH terms:
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Alzheimer Disease
Schizophrenia
Depressive Disorder
Depressive Disorder, Major
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mood Disorders