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Healthy Aging Longitudinal Study in Taiwan (HALST)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02677831
Recruitment Status : Active, not recruiting
First Posted : February 9, 2016
Last Update Posted : March 31, 2017
Sponsor:
Collaborators:
Shin Kong Wu Ho-Su Memorial Hospital
Hope Doctors Hospital
Changhua Christian Hospital
Puzi Hospital
Yuan's General Hospital
Mennonite Christian Hospital
CHC Hospital Group
Northwestern University
University of California, San Francisco
Information provided by (Responsible Party):
Chao A. Hsiung, National Health Research Institutes, Taiwan

Brief Summary:
The general aim of this study is to establish a longitudinal cohort of older persons in order to examine the physiological, environmental and genetic risk factors for physical disability, frailty, cardiovascular disease, and neuropsychiatric disorders in older persons and to examine the benefit of healthy lifestyles. The findings from this study will provide information necessary for the development of effective health policy for aging people.

Condition or disease
Cardiovascular Diseases Metabolic Diseases

Show Show detailed description

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Study Type : Observational
Actual Enrollment : 5664 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Healthy Aging Longitudinal Study in Taiwan (HALST)
Study Start Date : July 2008
Actual Primary Completion Date : March 2013
Estimated Study Completion Date : December 2020



Primary Outcome Measures :
  1. Independence in daily life assessed by Barthel Index [ Time Frame: 20 years ]
    The Barthel Index will be adapted to assess the ability to cope with 10 items of daily activities. These tasks include feeding, moving from wheelchair to bed, personal toilet, getting on and off the toilet, bathing, walking on a level surface, ascending and descending stairs, dressing, controlling bowel, and controlling bladder. The total score ranges from 0 to 100, with 100 representing full independence in doing daily activities.

  2. Independence in daily life assessed by Lawton-Brody Instrumental Activities of Daily Living (IADL) scale [ Time Frame: 20 years ]
    IADL scale is used to measure a participant's ability to adapt to the environment and consists of 8 tasks: shopping, housekeeping, money management, food preparation, laundry, transportation, use of the telephone, and medications. The total score is from 0 (worst) to 8 (best).

  3. Declined rate of physical performance assessed by peak flow test [ Time Frame: 20 years ]
    The peak flow test, is a measure of lung function, the participant is asked to take a deep breath and blow as fast and hard as possible into the meter at a standing or sitting position. The maximum value in liter per minute of three to five trials of forced expiration is chosen as the peak flow.

  4. Declined rate of physical performance assessed by grip strength [ Time Frame: 20 years ]
    The participant is instructed to use the dominant hand to grip the dynamometer as hard as possible three times. The maximum value in kilograms of three trials is recorded as maximal grip strength.

  5. Declined rate of physical performance assessed by Summary Physical Performance Battery (SPPB) [ Time Frame: 20 years ]
    The SPPB, is a measure of lower extremity function and represents the participant's performance on three performance-based tests: 4-meter timed walk, five chair stands, and balance in three different standing positions side by side, semi-tandem, and full tandem. Participants will receive a score of 0 to 4 for each test. The summary performance score is the sum of scores calculated across the three tests, with 0 representing the worst and 12 the best.

  6. Cardiovascular disease incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
  7. Dementia incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
  8. Overall cancer incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
  9. All cause mortality [ Time Frame: 20 years ]

Biospecimen Retention:   Samples With DNA
whole blood, serum, urine.


Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years to 104 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Investigators plan to conduct a longitudinal study on a cohort of 5,000+ men and women ages 55 years or older to address issues related to healthy aging. The study population consists community-based middle to old aged men and women in the catchment area of 7 hospitals (2 in the north, 2 in the middle, 2 in the south and 1 in the east, about half urban half rural). In this proposed study, investigators will recruit the subjects in the catchment area of the above 7 hospitals and expand data collection to include more interviewer-administered data, physical examinations and blood and urine specimens.
Criteria

Inclusion Criteria:

  • ages 55 years or older

Exclusion Criteria:

  • high transmitted disease (such as scabies, open pulmonary tuberculosis)
  • severe illness (such as cancer under treatment)
  • diagnosed dementia
  • severe illness and being bed-ridden, unable to move
  • severe mental disorder, cannot be communicated with(MMSE<16)
  • dumbness or hearing impairment, unable to complete the interview
  • unsighted completely, unable to complete the interview and test
  • < 55 years of age
  • Other conditions, such as living in a long-term care facility or being hospitalized

Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Chao A. Hsiung, Distinguished Investigator/Director, National Health Research Institutes, Taiwan
ClinicalTrials.gov Identifier: NCT02677831    
Other Study ID Numbers: EC0970608
First Posted: February 9, 2016    Key Record Dates
Last Update Posted: March 31, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Chao A. Hsiung, National Health Research Institutes, Taiwan:
Physical functioning
Neuropsychiatric Disorders
Frailty
Additional relevant MeSH terms:
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Metabolic Diseases
Cardiovascular Diseases