The Effects of Compensatory Auditory Stimulation and Transcranial Direct Current Stimulation on Tinnitus Perception
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|ClinicalTrials.gov Identifier: NCT02648542|
Recruitment Status : Completed
First Posted : January 7, 2016
Last Update Posted : January 7, 2016
|Condition or disease||Intervention/treatment||Phase|
|Tinnitus||Other: Compensatory auditory stimulation Device: transcranial direct current stimulation Other: Combined CAS and tDCS Other: Sham stimulation||Not Applicable|
Tinnitus refers to persistent "ringing in the ears" in absence of external sound. For some individuals tinnitus can be disabling. Most tinnitus is of idiopathic origin and currently there are no reliable treatment options available. Existing approaches, such as hearing aids, counseling, and noise masking typically provide only partial relief and only for a minority of patients. Newer exploratory methods include tailored auditory stimulation and various brain stimulation techniques. While these techniques show great promise in a subset of subjects (maybe about 1/3), it is hard to anticipate which, if any, will benefit a given patient.
Transcranial Direct Current Stimulation (tDCS) has been explored for a number of neurological conditions, and it is most effective when paired with some form of training (e.g. motor rehab after stroke). For tinnitus however this treatment modality has only been tested in isolation. The purpose of this pilot study is to explore the benefits of combining tailored compensatory auditory stimulation with tDCS.
There is widespread consensus in the research community that tinnitus originates with some peripheral hearing deficit, and that maladaptive central plastic mechanisms subsequently lead to the tinnitus percept. Most individuals with tinnitus have audiometric evidence of hearing loss. Our hypothesis is that reduced input to the auditory pathway leads to increased sensitivity (auditory gain) and finally aberrant activity in the frequency band with hearing loss. In this view, auditory stimulation that compensates for the reduced input can potentially revert the maladaptive plasticity.This is consistent with the reported benefits of hearing aids and tailored auditory stimulation. Our hypothesis is that tDCS can boost adaptation induced by compensatory auditory stimulation to reduce the strength of the phantom percept.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Effects of Compensatory Auditory Stimulation and Transcranial Direct Current Stimulation on Tinnitus Perception|
|Study Start Date :||March 2013|
|Actual Primary Completion Date :||July 2014|
|Actual Study Completion Date :||July 2014|
Active Comparator: CAS vs. tDCS
Assess the efficacy of compensatory auditory stimulation (CAS) versus transcranial direct current stimulation (tDCS)
Other: Compensatory auditory stimulation
Compensating for peripheral hearing loss by adjusting sound levels based on individual audiogram.
Other Name: CAS
Device: transcranial direct current stimulation
Low-current electrical brain stimulation
Other Name: tDCS
Sham Comparator: Combined CAS+tDCS vs. Sham
Assess the efficacy of combined compensatory auditory stimulation (CAS) + transcranial direct current stimulation (tDCS) versus sham stimulation
Other: Combined CAS and tDCS
Combined auditory and electrical stimulation
Other Name: CAS + tDCS
Other: Sham stimulation
Other Name: Sham
- Reduction in minimum masking levels [ Time Frame: 2 weeks ]Measurement of the minimum masking level required to mask the subjective tinnitus loudness is assessed after each intervention.
- Reduction in tinnitus percept as assessed via the visual analog test of tinnitus loudness [ Time Frame: 2 weeks ]Measurement of the subjective loudness of the tinnitus percept is measured using the visual analog scale test after each intervention.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02648542
|Principal Investigator:||Lucas C Parra, Ph.D.||City College of New York, CUNY|