Adipose Derived Stem Cells Transplantation for Chronic Obstructive Pulmonary Disease
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|ClinicalTrials.gov Identifier: NCT02645305|
Recruitment Status : Unknown
Verified December 2015 by Phuc Van Pham, University of Science Ho Chi Minh City.
Recruitment status was: Recruiting
First Posted : January 1, 2016
Last Update Posted : January 1, 2016
Chronic obstructive pulmonary disease (COPD) is the name for a collection of lung diseases including chronic bronchitis, emphysema and chronic obstructive airways disease. People with COPD have difficulties breathing, primarily due to the narrowing of their airways, this is called airflow obstruction.
Some preclinical evaluations showed that COPD is closely related to chronic inflammation; therefore, this study aimed to use adipose-derived stem cells (ADSCs) in the form of non-expanded culture - that usually names as a stromal vascular fraction (SVF) in combination with activated platelet rich plasma (PRP) to treat this disease. Both SVF and PRP are autologous sources that obtained from adipose tissue and peripheral blood, respectively. This mixture is intravenously transfused into the patients.
|Condition or disease||Intervention/treatment||Phase|
|COPD||Biological: Adipose derived stem cells||Phase 1 Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Evaluation of Safety and Efficacy of Autologous Adipose Derived Stem Cells Transplantation for Chronic Obstructive Pulmonary Disease|
|Study Start Date :||June 2015|
|Estimated Primary Completion Date :||September 2016|
|Estimated Study Completion Date :||December 2016|
Autologous stromal vascular fraction (SVF) and platelet rich plasma (PRP) will be transfused into 20 COPD patients.
Biological: Adipose derived stem cells
Adipose derived stem cells that are isolated from adipose tissue are mesenchymal stem cells with high immune modulation capacity. Therefore, they can effectively modulate the immune system.
- SGOT [ Time Frame: 1 month ]The blood SGOT levels are thus elevated with liver damage
- SGPT [ Time Frame: 1 month ]The blood SGPT levels are thus elevated with liver damage
- Respiration rate [ Time Frame: 1 month, 6 months, 12 months ]
- 6 min walk test [ Time Frame: 1 month, 6 months, 12 months ]
- rates of panic attacks [ Time Frame: 1 month, 6 months, 12 months ]
- CRP concentration [ Time Frame: 6 months, 12 months ]The CRP concentration in the patients were evaluated before and after treatment for 6 and 12 months
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02645305
|Van Hanh Hospital||Recruiting|
|Ho Chi Minh City, Vietnam|
|Contact: Phuong Le Thi Bich, MSc., MD email@example.com|
|Principal Investigator: Phuong Le Thi Bich, MSc., MD|
|Principal Investigator: Chien Vo Duc, MD.|
|Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh||Recruiting|
|Ho Chi Minh, Vietnam|
|Contact: Phuc V Pham, PhD +84903870153 firstname.lastname@example.org|
|Principal Investigator: Phuc V Pham, PhD|
|Nguyen Tri Phuong Hospital||Recruiting|
|Ho Chi Minh, Vietnam|
|Contact: Chien Vo Duc, MD. email@example.com|