The Impact of Bariatric Surgery Induced Weight Loss on Lung Function in Adolescents
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Impact of Bariatric Surgery Induced Weight Loss on Lung Function in Adolescents|
- Change from Baseline Lung Clearance Index [ Time Frame: 3 months post op ]
- Change from Baseline High sensitivity C reactive protein [ Time Frame: 3 months post op ]
|Study Start Date:||May 2016|
|Estimated Study Completion Date:||January 2020|
|Estimated Primary Completion Date:||January 2019 (Final data collection date for primary outcome measure)|
Morbid obesity leads to restrictive as well as obstructive ventilatory defects via mechanisms that include mechanical, as well as inflammatory factors. We hypothesise that multiple breath nitrogen washout will be more sensitive to changes in small airway function than conventional lung function testing.
We will invite adolescents with morbid obesity, scheduled to undergo bariatric surgery at SCMCI during 2016-2018, for pulmonary function testing, including spirometry, plethysmography, nitrogen multiple breath washout, lung transfer factor and 6 minute walk. These tests will be conducted prior to the operation as well as during follow-up appointments at 3, 6 and 12 months. We will also evaluate oxidative stress using highly sensitive C-reactive protein as surrogate marker.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02644174
|Contact: Patrick Stafler, MDemail@example.com|
|Schneider Children's Medical Center of Israel||Recruiting|
|Petach Tikva, Israel, 49202|
|Contact: Patrick Stafler, MD 972547243623 firstname.lastname@example.org|