Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock (SCLM)
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|ClinicalTrials.gov Identifier: NCT02640846|
Recruitment Status : Unknown
Verified December 2015 by Keti Dalla, Sahlgrenska University Hospital, Sweden.
Recruitment status was: Active, not recruiting
First Posted : December 29, 2015
Last Update Posted : November 29, 2018
|Condition or disease||Intervention/treatment||Phase|
|Septic Shock Cardiomyopathy||Drug: Norepinephrine Drug: Milrinone Drug: Levosimendan||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Potential Differences Between Levosimendan and Milrinone on Myocardial and Hemodynamic Variables in Patients With Septic Cardiomyopathy. Effects of Norepinephrine on Right Ventricular Function in Patient With Septic Shock.|
|Study Start Date :||December 2015|
|Estimated Primary Completion Date :||January 2019|
|Estimated Study Completion Date :||January 2019|
Active Comparator: Norepinephrine
Norepinephrine will be given to the patient due to septic shock. After the inclusion we will change the dose of Norepinephrine to achieve 3 different MAP-levels, 60 mmHg, 75 mmHg and 90 mmHg.
Active Comparator: Milrinone
Corotrope will be given and after 30 minutes of treatment the cardiac function will be assessed with echocardiography and systemic hemodynamics.
Other Name: Corotrope
Active Comparator: Levosimendan
Levosimendan will be given and after 30 minutes of treatment the cardiac function will be assessed with echocardiography and systemic hemodynamics.
Other Name: Simdax
- Changes in LV systolic strain [ Time Frame: 1.5 hours ]Changes in LV systolic function (global strain) will be assessed by 2D speckle tracking echocardiography
- Changes in RV systolic strain [ Time Frame: 1.5 hours ]Changes in RV systolic function (RV free wall strain) will be assessed by 2D speckle tracking echocardiography
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02640846
|Central intensivvårdsavdelning Sahlgrenska University Hospital|
|Gothenburg, Västra Götaland, Sweden, 41345|
|Study Chair:||Sven-Erik Ricksten, Professor||Sahlgrenska Academy, dep of clinical science|