The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter
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ClinicalTrials.gov Identifier: NCT02631083 |
Recruitment Status :
Completed
First Posted : December 15, 2015
Last Update Posted : August 2, 2017
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Condition or disease | Intervention/treatment | Phase |
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Type 2 Diabetes, Obesity, Prediabetes | Other: Breakfast, lunch, snack and dinner | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 15 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Other |
Official Title: | The Impact of a Low Glycaemic Index (GI) Diet on Daily Blood Glucose Profiles and Energy Flux in Male Chinese Adults. |
Actual Study Start Date : | November 14, 2014 |
Actual Primary Completion Date : | July 31, 2017 |
Actual Study Completion Date : | July 31, 2017 |

Arm | Intervention/treatment |
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Experimental: Breakfast, lunch, snack and dinner (high GI)
Subjects will consume meals which are high glycemic index for breakfast (Honey stars cereal), lunch (glutinous rice meal) and snack (white bread and jam) in the whole body calorimeter. A take-away high glycemic index dinner will be provided.
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Other: Breakfast, lunch, snack and dinner
These meals (cereal, rice and bread meals) will be tested in subjects for their glycaemic response (CGMS) and substrate utilization (calorimeter) |
Experimental: Breakfast, lunch, snack and dinner (low GI)
Subjects will consume meals which are low glycemic index for breakfast (All bran cereal), lunch (basmati rice meal) and snack (multigrain bread and sugar-free jam) in the whole body calorimeter. A take-away low glycemic index dinner will be provided.
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Other: Breakfast, lunch, snack and dinner
These meals (cereal, rice and bread meals) will be tested in subjects for their glycaemic response (CGMS) and substrate utilization (calorimeter) |
- Glycaemic response The blood glucose response to low and high GI test foods measured 2 hours post consumption using the Continuous Glucose Monitoring System (CGMS) [ Time Frame: 2 hours post consumption ]
The blood glucose response to low and high GI test foods measured 2 hours post consumption using the Continuous Glucose Monitoring System (CGMS)
The blood glucose response to low and high GI test foods measured 2 hours post consumption using the Continuous Glucose Monitoring System (CGMS)
- Daily blood glucose profile [ Time Frame: 24 hours ]The daily total blood glucose response is measured for each low and high GI treatment as the area under the curve over 24 hours using CGMS for breakfast, lunch, snack and dinner.
- Substrate oxidation [ Time Frame: 2 hours post consumption ]The carbohydrate and fat oxidation (i.e Respiratory Quotient) after consumption of low and high GI test foods measured 2 hours post consumption using indirect calorimetry in a whole body calorimeter. This is done over 10 hours in the whole body calorimeter measured for breakfast, lunch and snack only

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Ages Eligible for Study: | 21 Years to 40 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Chinese, male
- Age between 21-40 years
- Body mass index between 17 to 25 kg/m2
- Normal blood pressure (<140/80 Hgmm)
- Fasting blood glucose < 6 mmol/L
Exclusion Criteria:
- Having any metabolic diseases (such as diabetes, hypertension etc)
- On prescription medication
- Having glucose 6-phosphate dehydrogenase deficiency (G6PD)
- Partaking in sports at the competitive and/or endurance levels
- Allergic/intolerant to any of the test foods
- Intentionally restricting food intake
- Smoking
Responsible Party: | JeyaKumar Henry, Principal Investigator, Clinical Nutrition Research Centre, Singapore |
ClinicalTrials.gov Identifier: | NCT02631083 |
Other Study ID Numbers: |
2014/00960 |
First Posted: | December 15, 2015 Key Record Dates |
Last Update Posted: | August 2, 2017 |
Last Verified: | August 2017 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Plan Description: | No plan to share data |
Prediabetic State Diabetes Mellitus Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases |