Multicenter Trial Treatment of Philadelphia Chromosome Negative B-cell Acute Lymphoblastic Leukemia of Young Adults (GRAALL-2014/B)
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The purpose of this study is to prospectively validate the new risk model, based on minimal residual disease (MRD) response level and oncogenetic status by comparing historical results of GRAALL-2005 with those of GRAALL-2014 in an identical population of patients (Philadelphia chromosome negative, B lineage ALL, aged 18 to 59 years old).
Condition or disease
Philadelphia Chromosome Negative Adult B-cell Acute Lymphoblastic Leukemia
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Ages Eligible for Study:
18 Years to 59 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Young Adults (age 18-59) with Philadelphia Chromosome Negative B-cell Acute Lymphoblastic Leukemia
Whose blood and bone marrow explorations have been completed before the steroids prephase
Aged 18 to 59 years old with not previously treated (including intrathecal injection) B-lineage-ALL newly diagnosed according to the WHO 2008 definition with ≥ 20% bone marrow blasts
Whose karyotype shows no t(9;22) and/or the absence in molecular biology of breakpoint cluster region-Abelson (BCR-ABL)
With Eastern Cooperative Oncology Group (ECOG) performance status ≤3
With or without central nervous system (CNS) or testis involvement
Without other evolving cancer (except basal cell carcinoma of the skin or "in situ" carcinoma of the cervix) or its radiotherapy or chemotherapy treatment should be finished at least since 6 months
Having signed a written informed consent
With efficient contraception for women of childbearing age (excluding estrogens and IUD)
With health insurance coverage
Who have received or being receiving the steroid prephase
With lymphoblastic lymphoma and bone marrow blasts < 20%, Burkitt-type ALL, or with antecedents of chronic myeloid leukemia (CML) or other myeloproliferative neoplasm
With contra-indication to anthracyclines or any other general or visceral contra-indication to intensive therapy except if considered related to the ALL:
Aspartate transaminase (AST) and/or alanine transaminase (ALT) > 5 x upper limit of normal range (ULN)
Total bilirubin ≥ 2.5 x upper limit of normal range (ULN)
Creatinine >1.5x upper limit of normal range (ULN) or creatinine clearance <50 mL/mn
Myocardial infarction within 6 months prior to inclusion in the trial, cardiomyopathy (NYHA grade III or IV), left ventricle ejection fraction (LVEF) < 50% and or Shortening fraction < 30%,
Active severe infection or known seropositivity for HIV or human T cell leukemia/lymphoma virus type 1 (HTLV1) or active hepatitis B or C
Pregnant (beta-Human Chorionic Gonadotropin positive) or nursing woman
Not able to bear with the procedures or the frequency of visits planned in the trial
Unable to consent, under tutelage or curators, or judiciary safeguard.