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Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine

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ClinicalTrials.gov Identifier: NCT02615314
Recruitment Status : Completed
First Posted : November 26, 2015
Last Update Posted : November 26, 2015
Sponsor:
Information provided by (Responsible Party):
Sertac Yetiser, Anadolu Medical Center

Brief Summary:
The aim of this study is to analyze the clinical aspects of patients with BPPV associated with migraine. It is our purpose to clarify weather migraine is a risk factor for BPPV if the clinical aspect and the therapeutic outcome is different.

Condition or disease Intervention/treatment
Migraine Positional Vertigo Procedure: Particle re-positioning maneuver

Detailed Description:
Two hundred and sixty-three patients with BPPV were enrolled in this retrospective study. All patients' charts were reviewed by independent observer. The type of BPPV and associated problems were noted. Patients with migraine were investigated in terms of age, gender, symptoms, affected side and the cure rate. Their data were compared with those having no migraine. Mean values and standard deviations (± SD) were calculated. One way ANOVA test was used for the analysis. Significance was set at p < 0.005.

Study Type : Observational
Actual Enrollment : 232 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine
Study Start Date : January 2015
Actual Primary Completion Date : June 2015
Actual Study Completion Date : July 2015


Group/Cohort Intervention/treatment
BPPV without migraine
Two hundred and sixty-three patients with BPPV (2009-2014), confirmed by videonystagmography (VNG), were enrolled in the study. Patients' charts were reviewed. They were grouped as those with or without migraine. Distribution of gender, age, duration of symptoms and affected side were reviewed. Two hundred and thirty-one patients with no migraine were identified.
Procedure: Particle re-positioning maneuver
Patients with posterior canal BPPV (PC-BPPV) were treated with Epley maneuver. Patients with superior canal (SC-BPPV) were treated with Li or reverse Epley maneuver. Patients with lateral canal (LC) apogeotropic or geotropic nystagmus were treated with Barbeque, Semont's or Gufoni maneuvers. If geotropic or ageotropic type nystagmus is equal intensity on both sides. The involved side was determined according to the patient sense of disturbance or lying down positioning test. If the patient has involvement of both sides according to Dix-Hallpike maneuver. Therapeutic maneuver was applied to the more severe side. All patients were re-evaluated at maximum 7 days.

BPPV with migraine
Thirty-two patients (11.4%) with migraine were identified. Diagnosis and classification of migraine and its differentiation from other type of headaches was based on third edition of International classification of headache disorders (ICHD-III beta) by international headache society (IHS). All patients with migraine had migrainous headache with or without aura and they all were diagnosed in our institution and followed by our neurology staff.
Procedure: Particle re-positioning maneuver
Patients with posterior canal BPPV (PC-BPPV) were treated with Epley maneuver. Patients with superior canal (SC-BPPV) were treated with Li or reverse Epley maneuver. Patients with lateral canal (LC) apogeotropic or geotropic nystagmus were treated with Barbeque, Semont's or Gufoni maneuvers. If geotropic or ageotropic type nystagmus is equal intensity on both sides. The involved side was determined according to the patient sense of disturbance or lying down positioning test. If the patient has involvement of both sides according to Dix-Hallpike maneuver. Therapeutic maneuver was applied to the more severe side. All patients were re-evaluated at maximum 7 days.




Primary Outcome Measures :
  1. Number of patients who had normal vestibular response to provocative tests 7 days after re-positioning maneuver [ Time Frame: 7 days ]
    Every patient with BPPV who had positional nystagmus during Dix-Hallpike and head-roll provocative maneuvers will be treated with Epley or barbeque particle re-positioning maneuvers. Balance (positional nystagmus) of patients 7 days after re-positioning maneuvers will be assessed.



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Ages Eligible for Study:   10 Years to 84 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
BPPV patients only confirmed by VNG
Criteria

Inclusion Criteria:

  • Patients who had history of head-induced positional and brief vertigo and who have been confirmed by VNG were included

Exclusion Criteria:

  • Patients with balance problem other than BPPV,
  • Patients receiving any medication prior to therapeutic maneuver were excluded

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02615314


Sponsors and Collaborators
Anadolu Medical Center
Investigators
Principal Investigator: Meltem Hale Gokmen, MD Dept of Neurology, Anadolu Medical Center

Publications of Results:
Responsible Party: Sertac Yetiser, Clinical Professor, Dept of ORL & HNS, Anadolu Medical Center
ClinicalTrials.gov Identifier: NCT02615314     History of Changes
Other Study ID Numbers: AnadoluMC
First Posted: November 26, 2015    Key Record Dates
Last Update Posted: November 26, 2015
Last Verified: November 2015

Keywords provided by Sertac Yetiser, Anadolu Medical Center:
migraine
benign paroxysmal positional vertigo

Additional relevant MeSH terms:
Migraine Disorders
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vestibular Diseases
Labyrinth Diseases
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Vertigo
Dizziness
Benign Paroxysmal Positional Vertigo
Neurologic Manifestations
Signs and Symptoms