Pituitary Function and Spontaneous Intracranial Hypotension
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ClinicalTrials.gov Identifier: NCT02603549
Recruitment Status :
(Study protocol needs to be amended. Recruitment is halted until amendment is completed and approved by IRB.)
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with Spontaneous intracranial hypotension (SIH)
Male or female patients
Age 18 years and older
Diagnosis of SIH:
Brain MRI (SEEPS)
Pregnant and post-partum females
Patients with potential hyperprolactinemia due to: