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The Effect of Phosphorus on Diet Induced Thermogenesis

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ClinicalTrials.gov Identifier: NCT02594787
Recruitment Status : Completed
First Posted : November 3, 2015
Last Update Posted : November 3, 2015
Sponsor:
Information provided by (Responsible Party):
Maya Bassil, Lebanese American University

Study Description
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Brief Summary:
The aim of the trial is to investigate the effect of ingestion of 75g of glucose (with or without phosphorus) on diet induced thermogenesis (using indirect calorimetry) and appetite (using visual analogue scales) in lean and obese healthy subjects

Condition or disease Intervention/treatment Phase
Imbalance of Constituents of Food Intake Healthy Dietary Supplement: Phosphorus Dietary Supplement: Placebo Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 23 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Study Start Date : March 2011
Actual Primary Completion Date : January 2014
Actual Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

Drug Information available for: Phosphorus

Arms and Interventions
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Arm Intervention/treatment
Active Comparator: Phosphorus
Intervention (500 mg of potassium phosphate) will be administered with 75 g glucose solution and diet induced thermogenesis will be measured afterwards
 Dietary Supplement: Phosphorus
Placebo Comparator: Placebo
Placebo (cellulose) will be administered with 75 g glucose solution and diet induced thermogenesis will be measured afterwards
 Dietary Supplement: Placebo


Outcome Measures
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Primary Outcome Measures :
  1. Diet Induced Thermogenesis [ Time Frame: 180 minutes (measured every 30 min) ]
    Diet Induced Thermogenesis will be measured using indirect calorimetry (VO2 consumption)


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Sedentary lifestyle
  • Stable weight for the past 3 months
  • On a balanced diet

Exclusion Criteria:

  • Underweight (BMI<18.5) or overweight/obese (BMI≥25)
  • age <18 or > 30 years
  • Inability to give valid consent
  • Presence of a chronic or acute illness.
  • Elevated physical activity level (assesses by the physical activity questionnaire)
  • Heavy smokers (≥1 pack per day).
  • Weight gain or loss of > 3% in the past 3 months
  • History of kidney stones
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02594787


Sponsors and Collaborators
Lebanese American University
Investigators
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Principal Investigator: Maya Bassil, PhD Lebanese American University
More Information
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Responsible Party: Maya Bassil, Assistant Professor, Lebanese American University
ClinicalTrials.gov Identifier: NCT02594787    
Other Study ID Numbers: LAU.SOAS.MB1.2012.R1.11
First Posted: November 3, 2015    Key Record Dates
Last Update Posted: November 3, 2015
Last Verified: November 2015