Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
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|ClinicalTrials.gov Identifier: NCT02592616|
Recruitment Status : Unknown
Verified June 2016 by Anders Rasmussen Rinnov, Rigshospitalet, Denmark.
Recruitment status was: Active, not recruiting
First Posted : October 30, 2015
Last Update Posted : June 22, 2016
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- One hour of rest (CON)
- One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
- One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Mellitus, Type 2||Behavioral: CON Behavioral: CW Behavioral: IW||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||14 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Interval-training and Appetite Regulation in Patients With Type 2 Diabetes|
|Study Start Date :||October 2015|
|Actual Primary Completion Date :||June 2016|
|Estimated Study Completion Date :||October 2016|
No exercise intervention.
Continuous Walking (CW).
One hour of continuous walking on a treadmill.
Interval Walking (IW).
One hour of interval (repeated cycles of 3 minutes of fast and 3 minutes of slow) walking on treadmill.
- Ad-libitum meal energy intake [ Time Frame: Initiated 3 hours after the intervention ]Subjects will receive a standardized ad-libitum meal and energy intake will be assessed
- Free-living energy intake [ Time Frame: For 32 hours following the ad-libitum meal. ]Subjects will complete diet records for 32 hours following the ad-libitum meal and energy intake will be assessed.
- Appetite-related hormones [ Time Frame: Regularly during the 3 hours following the intervention ]Appetite-related hormones (insulin, ghrelin, leptin, cholecyctokinin, PYY) will be analysed in blood samples collected regularly during the liquid mixed-meal tolerance test following the intervention
- Satiety [ Time Frame: Regular assessments for 36 hours following the intervention ]Satiety questionaires will be completed at regular intervals after the intervention
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02592616
|Center for Physical Activity Research (CFAS)|
|Copenhagen, Denmark, 2100|