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Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02592122
Recruitment Status : Unknown
Verified October 2015 by snow, Beijing Chao Yang Hospital.
Recruitment status was:  Recruiting
First Posted : October 30, 2015
Last Update Posted : October 30, 2015
Primary-investigator,Bing Sun
Information provided by (Responsible Party):
snow, Beijing Chao Yang Hospital

Brief Summary:
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Condition or disease Intervention/treatment Phase
Lung Disease,Obstructive Drug: Salbutamol Aerosol Drug: No drugs Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : October 2013
Estimated Primary Completion Date : October 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Diseases

Arm Intervention/treatment
Active Comparator: Atomization inhalation
First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group
Drug: Salbutamol Aerosol
Other Name: Ammonium bromide bromide aerosol

Active Comparator: Without atomization inhalation
First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group
Drug: No drugs

Primary Outcome Measures :
  1. airway resistance [ Time Frame: 1 day ]
    The first test of bronchial dilatation

  2. Respiratory mechanics index:PEEPi [ Time Frame: 1 day ]

Secondary Outcome Measures :
  1. Mechanical ventilation time [ Time Frame: 28 days ]
  2. length of hospital stay [ Time Frame: 30 days ]
  3. Costs of hospitalization expenses [ Time Frame: 30 days ]
  4. Routine blood test:Eosinophilic cells [ Time Frame: 7days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute exacerbation of chronic obstructive pulmonary disease
  • The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion Criteria:

  • asthma
  • has received tracheotomy
  • long term mechanical ventilation (which has been accepted for more than 21 days).
  • severe pneumonia
  • Patients who cannot use a patient with bronchial dilation
  • there's a taboo on the use of a sedative.
  • refusal to participate in the study
  • 48 hours to pull out the tube

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02592122

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Contact: Xue Wang, MB 0086-10-85231543
Contact: Sun Bing, MD 86013911151075

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China, Beijing
Department of respiratory and critical care medicine,Beijing Chao-yang Hospital Recruiting
Beijing, Beijing, China, 100020
Contact: Xue Wang, MB    0086-10-85231543   
Contact: Bing Sun, MD    86013911151075   
Sponsors and Collaborators
Primary-investigator,Bing Sun
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Principal Investigator: Bing Sun Beijing Chao Yang Hospital

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Responsible Party: snow, , Beijing Chao Yang Hospital Identifier: NCT02592122     History of Changes
Other Study ID Numbers: 2013-10-COPD
First Posted: October 30, 2015    Key Record Dates
Last Update Posted: October 30, 2015
Last Verified: October 2015
Keywords provided by snow, Beijing Chao Yang Hospital:
Mechanical ventilation
Chronic obstructive pulmonary disease
Airway resistance
Bronchial dilation test
Additional relevant MeSH terms:
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Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Diseases
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Tocolytic Agents
Reproductive Control Agents
Adrenergic beta-2 Receptor Agonists
Adrenergic beta-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action