Strength Training Adaptations, Age and Genes (STAGE)
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|ClinicalTrials.gov Identifier: NCT02589990|
Recruitment Status : Completed
First Posted : October 28, 2015
Last Update Posted : September 28, 2018
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Behavioral: Strength training||Not Applicable|
Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.
Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.
Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||76 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Maximal Strength Training in Relation to Age and Genes|
|Study Start Date :||January 2016|
|Actual Primary Completion Date :||August 2018|
|Actual Study Completion Date :||September 3, 2018|
Experimental: Strength training
Strength training, 4 rep of 4RM x 4 sets in leg press.
Behavioral: Strength training
see arm description
- Maximal muscle strength measured by 1 RM leg press in leg press machine [ Time Frame: 8 weeks ]
- Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen [ Time Frame: 8 weeks ]
- rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway) [ Time Frame: 8 weeks ]
- agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway) [ Time Frame: 8 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02589990
|Telemark University College|
|Bø, Telemark, Norway, 3800|
|Norwegian University of Science and Technology|
|Study Chair:||Øyvind Støren, PhD||Telemark University College|
|Study Director:||Mona Sæbø, PhD||Telemark University College|