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"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."

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ClinicalTrials.gov Identifier: NCT02583841
Recruitment Status : Completed
First Posted : October 22, 2015
Last Update Posted : October 22, 2015
Sponsor:
Information provided by (Responsible Party):
Dr. Pradnya Rajendra Khatavkar, Tatyasaheb Kore Dental College

Brief Summary:

Aim:

To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects.

Materials and methods:

The study is non surgical interventional trial, includes 50 CP subjects in the age group of 35- 60 years selected from the OPD (Out Patient Department) of department of periodontology Tatyasaheb Kore Dental College and Research center (TKDC and RC), Kolhapur. CP subjects were equally divided into test group and control group. Liver function test- aspartate aminotransferase (AST), alanine aminotransferase (ALT) were checked at baseline and at 1 month after treatment. Clinical examination includes plaque index, gingival index, sulcus bleeding index, probing depth, clinical attachment loss.


Condition or disease Intervention/treatment Phase
Chronic Periodontitis (CP) Subjects. Procedure: Scaling and root planing Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Prevention
Study Start Date : February 2015
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Scaling and Root Planing( SRP)
This was an interventional study in which scaling and root planing was done in systemically healthy patients with chronic periodontitis
Procedure: Scaling and root planing
scaling and root planing as an intervention was done in patients of the test group

No Intervention: Control Group
Scaling and root planing was not done , that is no intervention is carried out in the patients of this group.



Primary Outcome Measures :
  1. Alanine aminotransferase [ Time Frame: 1month ]
  2. Aspartate aminotransferase [ Time Frame: 1 month ]

Secondary Outcome Measures :
  1. plaque index [ Time Frame: 1month ]
  2. gingival index [ Time Frame: 1 month ]
  3. sulcus bleeding index [ Time Frame: 1month ]
  4. probing depth [ Time Frame: 1month ]
  5. Clinical attachment loss [ Time Frame: 1 month ]


Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Subjects with CP (moderate and severe) as per Centers for disease control and prevention (CDC) criteria 2007.
  2. Patients without any known systemic diseases

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Exclusion Criteria:

  1. Patients who have taken anti-inflammatory/antibiotic/antioxidant within 3 months of beginning of study.
  2. Subjects who have undergone periodontal treatment within six months of inception of study.
  3. Smokers, tobacco habits in any form and alcoholics.
  4. Pregnant and lactating women.

    -


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Responsible Party: Dr. Pradnya Rajendra Khatavkar, Post graduate student, Tatyasaheb Kore Dental College
ClinicalTrials.gov Identifier: NCT02583841     History of Changes
Other Study ID Numbers: TatyasahebKoreDentalC
First Posted: October 22, 2015    Key Record Dates
Last Update Posted: October 22, 2015
Last Verified: October 2015

Additional relevant MeSH terms:
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Periodontitis
Chronic Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases