Optical Coherence Tomography and Optic Neuritis (OCTON) (OCTON)
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|ClinicalTrials.gov Identifier: NCT02573792|
Recruitment Status : Active, not recruiting
First Posted : October 12, 2015
Last Update Posted : June 25, 2019
Optic neuritis (ON) can remain isolated or reveal a widespread and chronic disease of the central nervous system (CNS), a multiple sclerosis (MS) or, more rarely, a Devic's neuromyelitis optica (NMO) or a systemic disease.
The optical coherence tomography (OCT) is a retinal imaging technique to measure the thickness of the retina and its different layers with an accuracy of 4-6 µM.
Costello et al have shown that approximately 75% of 54 MS patients have developed within 3 to 6 months after a ON a loss of 10 to 40 µM in the thickness of the peripapillary retinal nerve fiber layer (RNFL).
The etiologic diagnosis of ON has been transformed in recent years. MS can now be diagnosed by McDonald's MRI criteria and NMO by the AQP4 antibodies (anti-aquaporin- 4) antibodies and the anti-MOG (myelin-oligodendrocyte glycoprotein) antibodies.
The diagnosis and prognosis value of the OCT in patients with ON is not well known
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||120 participants|
|Official Title:||Optical Coherence Tomography for the Etiological Diagnosis of Inflammatory Optic Neuritis|
|Actual Study Start Date :||October 5, 2015|
|Estimated Primary Completion Date :||July 2019|
|Estimated Study Completion Date :||July 2019|
- Sensitivity of the OCT, expressed as a percentage, for the etiological diagnosis of optical neuritis [ Time Frame: One year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02573792
|Fondation Ophtalmologique Adolphe de Rothschild|
|Paris, Ile De France, France, 75019|