COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02572362
Recruitment Status : Completed
First Posted : October 8, 2015
Last Update Posted : December 13, 2016
Klinik Hirslanden, Zurich
Information provided by (Responsible Party):
Daniel Rudolf Zwahlen, Kantonsspital Graubuenden

Brief Summary:
Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

Condition or disease Intervention/treatment
Neoplasms, Second Primary Other: No intervention in this retrospective study

Detailed Description:
A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.

Layout table for study information
Study Type : Observational
Actual Enrollment : 25 participants
Time Perspective: Retrospective
Official Title: Estimation of Second Cancer Risk in Patients Planned With Different Radiotherapy Regimes for Rectal Cancer - A Planning Study and Model-based Analysis
Study Start Date : August 2015
Actual Primary Completion Date : November 2016
Actual Study Completion Date : November 2016

Intervention Details:
  • Other: No intervention in this retrospective study
    No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study

Primary Outcome Measures :
  1. Calculation of the organ-specific excess lifetime attributable risk (LAR) (%) [ Time Frame: 60 years (model-based calculation) ]
    LAR is calculated for variable Ages at exposure

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 100 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients having had radiation therapy for rectal cancer. Estimation of second cancer risk using data from planning CTs comparing dose Distribution using different Radiation therapy techniques (3DCRT vs VMAT).

Inclusion Criteria:

  • Male/Female > 18 years of age
  • pre or postoperative radiation therapy for rectal cancer
  • Planning CT

Exclusion Criteria:

  • Planning CT not available

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02572362

Layout table for location information
Klinik Hirslanden, Institute for Radiotherapy
Zurich, Switzerland, CH-8032
Sponsors and Collaborators
Kantonsspital Graubuenden
Klinik Hirslanden, Zurich
Layout table for investigator information
Principal Investigator: Daniel R Zwahlen, MD, MBA Kantonsspital Graubuenden
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Daniel Rudolf Zwahlen, MD, MBA, Kantonsspital Graubuenden Identifier: NCT02572362    
Other Study ID Numbers: KEK-ZH-Nr. 2014-0255
First Posted: October 8, 2015    Key Record Dates
Last Update Posted: December 13, 2016
Last Verified: December 2016
Additional relevant MeSH terms:
Layout table for MeSH terms
Neoplasms, Second Primary