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MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers (MELA)

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ClinicalTrials.gov Identifier: NCT02570581
Recruitment Status : Completed
First Posted : October 7, 2015
Last Update Posted : October 7, 2015
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire de Nice

Brief Summary:
Elderly people often suffer from chronic pathologies and they are given polypharmacy. In case of swallowing problems, the drugs are crushed and mixed in food, which alters the taste of food and is a cause of anorexia and malnutrition. Gustative side-effects of crushed drugs have nether been investigated. The MELA study is a one session hedonic test involving 16 healthy volunteers. They will score in a blind manner the taste of 10 drugs commonly prescribed in nursing homes, crushed in jelly or apple compote. These volunteers will be 8 food professionals and 8 geriatric care professionals. Thanks to the MELA protocol, they will have a unique opportunity to communicate and propose solutions to this neglected aspect of malnutrition in elderly populations.

Condition or disease Intervention/treatment Phase
Healthy Other: Jelly with:Paracetamol Other: Jelly with Furosemide Other: Jelly with Levothyroxine sodium salt Other: Jelly with Memantine Other: Jelly with Zopiclone Other: Jelly with Alprazolam Other: Jelly with Oxazepam Other: Jelly with Donepezil Other: Jelly with Clopidogrel Other: Jelly with Ramipril Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam Other: Plain jelly control Other: Apple compote Paracetamol Other: Apple compote Furosemide Other: Apple compote Levothyroxine sodium salt Other: Apple compote Memantine Other: Apple compote Zopiclone Other: Apple compote Alprazolam Other: Apple compote Oxazepam Other: Apple compote Donepezil Other: Apple compote Clopidogrel Other: Apple compote Ramipril Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam Other: Plain apple compote control Phase 1

  Show Detailed Description

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Health Services Research
Official Title: MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers
Study Start Date : June 2014
Actual Primary Completion Date : July 2014
Actual Study Completion Date : July 2014


Arm Intervention/treatment
Placebo Comparator: Plain jelly control
Plain jelly control
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Jelly with: Paracetamol

Jelly with:

Paracetamol

Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Jelly with Furosemide
Jelly with Furosemide
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Jelly with memantine
Jelly with memantine
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with zopiclone
Jelly with zopiclone
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with alprazolam
elly with alprazolam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with Oxazepam
Jelly with Oxazepam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with donepezil
jelly with donepezil
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Jelly with clopidogrel
jelly with clopidogrel
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with ramipril
jelly with ramipril
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: jelly with Paracetamol + Furosemide + Levothyroxine sodium sa
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Placebo Comparator: Plain apple compote control
Plain apple compote control
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Active Comparator: Apple compote Paracetamol
Apple compote Paracetamol
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Furosemide
Apple compote Furosemide
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Memantine
Apple compote Memantine
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Zopiclone
Apple compote Zopiclone
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Alprazolam
Apple compote Alprazolam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Oxazepam
Apple compote Oxazepam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Donepezil
Apple compote Donepezil
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Clopidogrel
Apple compote Clopidogrel
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Ramipril
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple compote Ramipril
Apple compote Ramipril
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain apple compote control
Active Comparator: Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Other: Jelly with:Paracetamol

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.

The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.

The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.

Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.


Other: Jelly with Furosemide
Other: Jelly with Levothyroxine sodium salt
Other: Jelly with Memantine
Other: Jelly with Zopiclone
Other: Jelly with Alprazolam
Other: Jelly with Oxazepam
Other: Jelly with Donepezil
Other: Jelly with Clopidogrel
Other: Jelly with Ramipril
Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Other: Plain jelly control
Other: Apple compote Paracetamol
Other: Apple compote Furosemide
Other: Apple compote Levothyroxine sodium salt
Other: Apple compote Memantine
Other: Apple compote Zopiclone
Other: Apple compote Alprazolam
Other: Apple compote Oxazepam
Other: Apple compote Donepezil
Other: Apple compote Clopidogrel
Other: Apple compote Ramipril
Other: Plain apple compote control



Primary Outcome Measures :
  1. Quantitative- compare the taste between specimens [ Time Frame: 1 week after the test ]
    Quantitative: mark from 0 (bad taste) to 10 (no taste or no unpleasant taste) for the jelly and compote specimens added with crushed drugs.


Secondary Outcome Measures :
  1. qualitative - description of the perceived aroma [ Time Frame: 1 week after the test ]
    Qualitative: description of the perceived aroma (acid, bitter, sweet, salty, astringent, pricking, aromatic).



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy volunteers over 18 years.

Exclusion Criteria:

  • pregnant women. Women in age to borne children will perform a urinary test will just before the assay, under the supervision of the Clinical Research Center nurse.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02570581


Locations
Layout table for location information
France
Center for Clinical Research - Archet 1 Hospital Nice Hospital
Nice, France, 06200
Sponsors and Collaborators
Centre Hospitalier Universitaire de Nice

Layout table for additonal information
Responsible Party: Centre Hospitalier Universitaire de Nice
ClinicalTrials.gov Identifier: NCT02570581     History of Changes
Other Study ID Numbers: 2013-003461-34
First Posted: October 7, 2015    Key Record Dates
Last Update Posted: October 7, 2015
Last Verified: September 2015
Keywords provided by Centre Hospitalier Universitaire de Nice:
volonteeres
Additional relevant MeSH terms:
Layout table for MeSH terms
Crush Injuries
Wounds and Injuries
Acetaminophen
Ramipril
Furosemide
Memantine
Alprazolam
Zopiclone
Oxazepam
Donepezil
Clopidogrel
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Purinergic P2 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Antipyretics
Cholinesterase Inhibitors
Enzyme Inhibitors
Cholinergic Agents
Nootropic Agents
Antiparkinson Agents
Anti-Dyskinesia Agents