Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation
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|ClinicalTrials.gov Identifier: NCT02561858|
Recruitment Status : Completed
First Posted : September 28, 2015
Last Update Posted : March 12, 2018
Patients who are overweight or obese, diabetic or not, share with those who are suffering from uric stones the same way to remove abnormal acidity of the body in urine, ie a kidney ammoniogenesis default. This results in an overly acidic urine pH which is directly pathogenic in people predisposed to develop uric stones because the precipitation of urate soluble uric acid is accelerated in acid medium.
Excess visceral fat, particularly perirenal, this defect may promote formation of renal ammonium. Indeed, the perirenal fat is adjacent to the renal cortex and shares with it a common arterial supply via the plexus Turner. Adipokines and fatty acids of the perirenal fat are predisposed to gain the renal cortex, seat of the ammoniogenesis. In humans the pathogenic role of the perirenal fat is demonstrated in chronic kidney disease and essential hypertension. However, the amount of fat and perirenal that of intra-abdominal fat are positively correlated.
Investigators hypothesis is that the perirenal fat also exert a pathogenic role in uric because of anatomical links between kidney stones and greasy environment and because excess fatty acids reaching the renal cortex decreases ammoniogenesis in an animal model metabolic syndrome.
For the test, the investigators will compare the amount of fat and perirenal renal ability to form ammonium in patients with uric or calcium lithiasis taking into account the amount of intra-abdominal fat.
|Condition or disease||Intervention/treatment||Phase|
|Uric Acid Stones||Other: acid load test||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation|
|Actual Study Start Date :||October 14, 2015|
|Actual Primary Completion Date :||June 24, 2016|
|Actual Study Completion Date :||September 29, 2016|
|Experimental: acid load test||
Other: acid load test
- the perirenal fat thickness (left) [ Time Frame: baseline ]This is the perirenal fat thickness measured between the left posterior wall of the kidney and the posterior wall of the abdominal cavity on a TDM section in the plane of the left renal vein.
- the perirenal fat thickness (right) [ Time Frame: baseline ]the average thickness of perirenal fat measured to the right
- NH4 + / NAE [ Time Frame: at day 7 of a standard diet ]It is the ratio NH4 + / NAE measured over 24 hours of urine collected at day 7 of a standard diet; it determines from acid removed as ammonium whose production is regulated physiologically by the kidneys
- net acid urinary flow [ Time Frame: at day 7 of a standard diet and when urine pH became <5.5 ]This is the net acid urinary flow and report NH4 + / creat obtained when the urine pH became <5.5, in an acidic filler.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02561858
|CHU de Nice|
|Nice, France, 06000|