Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
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|ClinicalTrials.gov Identifier: NCT02559063|
Recruitment Status : Completed
First Posted : September 24, 2015
Last Update Posted : October 2, 2019
|Condition or disease||Intervention/treatment||Phase|
|Mild Cognitive Impairment||Behavioral: Vision-based speed of processing training Behavioral: Mental leisure activities||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||84 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults With Mild Cognitive Impairment|
|Actual Study Start Date :||January 12, 2016|
|Actual Primary Completion Date :||October 9, 2018|
|Actual Study Completion Date :||July 1, 2019|
Experimental: Vision-based speed of processing
Vision-based speed of processing training will use the INSIGHT online program (Posit Science), which includes five games (i.e., Eye for detail, Peripheral challenge, Visual sweep, Double decision, Target tracker) that practice processing speed and attention. All games share visual components, and the tasks become increasingly more difficult and require faster reaction times. Participants respond either by identifying what object they see or where they see it on the screen. The training will automatically adjust the difficulty of each task based on the participant's performance, ensuring that the participants always operate near their optimal capacity. The training programs will automatically record the percentage of completion of each game and scores.
Behavioral: Vision-based speed of processing training
computerized cognitive tasks addressing vision-based speed of processing
Active Comparator: Mental leisure activities
Mental leisure activities control activities were chosen to: 1) control for computer, online experience [and amount of time]; 2) not induce acute stress (i.e., without time management, speed component, or novel cognitive stimuli); 3) simulate participants' everyday mental activities; and 4) entertain participants to keep them from dropping out. Cross-word, Sudoku, and solitaire games will be used, which were also used in previous VSOP training study as control exercises. Participants can choose to practice any combination of games. At the end of their participation, the MLA control group will be provided with free 6-week access to the VSOP training program.
Behavioral: Mental leisure activities
computerized cognitive tasks addressing different aspects of executive function
- Attention and processing speed test (UFOV) [ Time Frame: change from baseline to 6-month follow-up ]
- Cognitive control and working memory (EXAMINER) [ Time Frame: change from baseline to 6-month follow-up ]
- instrumental activities of daily living (TIADL) [ Time Frame: change from baseline to 6-month follow-up ]
- mean of functional connectivity in default mode network [ Time Frame: change from baseline to 6-month follow-up ]Resting state fMRI will be used to assess the functional connectivity of the neural network. SPM will be used to analyze and determine the change of the connectivity over time.
- mean of structural connectivity in default mode network [ Time Frame: change from baseline to 6-month follow-up ]Diffusion tensor imaging will be used to assess the structural connectivity of the neural network. FSL will be used to analyze and determine the change of the connectivity over time.
- long-term visual memory [ Time Frame: change from baseline to 6-month follow-up ]long-term visual memory will be assessed using Brief Visuospatial Memory Test (BVMT)-R.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02559063
|United States, New York|
|University of Rochester Memory Care Program|
|Rochester, New York, United States, 14642|
|Principal Investigator:||Vankee Lin, PhD||University of Rochester|