Shortening of the Twitch Stabilization Period by Tetanic Stimulation in Acceleromyography in Children and Young Adults (STSTS)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02552875|
Recruitment Status : Completed
First Posted : September 17, 2015
Last Update Posted : September 17, 2015
Repetitive nerve stimulation is used to monitor the neuromuscular transmission function in infants, children and adults after the application of muscle relaxants. During repetitive stimulation of a motor nerve, amplitude of contractions of the corresponding muscle will increase to a plateau (twitch potentiation), which is known as the staircase phenomenon.
There is no systematic information about the staircase phenomenon of the adductor pollices muscle (ulnar nerve) in children between 1 month and 18 years .
In adults , a 50-Hz tetanus administered before initial twitch stabilization is able to shorten the twitch stabilization period and to eliminate this staircase phenomenon.
The purpose of this study is to investigate the characteristics of twitch potentiation in children between 1 month and 18 years by using acceleromyography.
In addition we investigate whether application of a 50-Hz tetanic stimulation is able to eliminate the twitch potentiation like in adults.
|Condition or disease||Intervention/treatment||Phase|
|Train-of-Four-Monitoring||Other: Tetanic stimulation Other: Staircase Stimulation||Phase 4|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||80 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Shortening of the Twitch Stabilization Period by Tetanic Stimulation in Acceleromyography in Children and Young Adults|
|Study Start Date :||September 2014|
|Actual Primary Completion Date :||September 2015|
|Actual Study Completion Date :||September 2015|
Active Comparator: Tetanic Stimulation
50 Hz tetanic stimulation for 5 seconds before TOF-twitch stabilization at the one arm
Other: Tetanic stimulation
50 Hz tetanic stimulation before TOF-twitch stabilization with the aim to eliminate the staircase phenomenon
Active Comparator: Staircase Stimulation
TOF-twitch stabilisation without 50 Hz tetanic stimulation at the contralateral arm
Other: Staircase Stimulation
TOF-twitch stabilization without 50 Hz tetanic stimulation with the aim to verify the staircase phenomenon
- T1% measurement [ Time Frame: 30 minutes ]T1% increase dependent on stimulation with and without a 50 Hz tetanic stimulation
- TOFR% maesurement [ Time Frame: 30 minutes ]TOFR%course dependent on stimulation with and without a 50 Hz tetanic stimulation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02552875
|University Medical Center Regensburg, Department of Anaesthesiology|
|Regensburg, Germany, 93055|
|Principal Investigator:||Christoph Unterbuchner, MD||University Medical Center Regensburg, Germany|