PAI-1 Expression in Non-scarring Hair Loss
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|ClinicalTrials.gov Identifier: NCT02548689|
Recruitment Status : Recruiting
First Posted : September 14, 2015
Last Update Posted : January 23, 2018
|Condition or disease|
|Androgenetic Alopecia Telogen Effluvium Alopecia Areata|
|Study Type :||Observational|
|Estimated Enrollment :||55 participants|
|Official Title:||Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.|
|Study Start Date :||July 2015|
|Estimated Primary Completion Date :||December 2018|
|Estimated Study Completion Date :||June 2019|
Non-scarring hair loss
Patients seen at Northwestern Memorial Hospital or Northwestern Medical Faculty Foundation physician offices that have undergone evaluation for hair loss and have a diagnosis of androgenetic alopecia, telogen effluvium or alopecia areata.
Age-matched controls who do not have a history of hair loss and have normal scalp skin without evidence of hair loss.
- PAI-1 expression level in scalp skin biopsy samples [ Time Frame: Baseline ]Tissue PAI-1 expression levels will be determined by immunohistochemistry, a three-layer biotin-strepavidin system. Positive PAI-1 expression per total tissue area will be quantified using the color-picker function in imaging software.The PAI-1 expression found in normal scalps will be compared to those found in scalps with hair loss.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02548689
|Contact: Yasmeen Aliemail@example.com|
|United States, Illinois|
|Northwestern University Department of Dermatology||Recruiting|
|Chicago, Illinois, United States, 60611|
|Contact: Yasmeen Ali 312-503-5906 firstname.lastname@example.org|
|Principal Investigator: Maria Colavincenzo, MD|
|Sub-Investigator: Douglas Vaughan, MD|
|Sub-Investigator: Ekaterina Klyachko, PhD|
|Sub-Investigator: Sheila Murphy|
|Principal Investigator:||Maria Colavincenzo, MD||Northwestern University Feinberg School of Medicine|