The Benefits of Hemp Protein Supplementation During Resistance Training

• ClinicalTrials.gov Identifier: NCT02529917
• Recruitment Status: Completed
• First Posted: August 20, 2015
• Last Update Posted: May 5, 2017
• Sponsor: University of Saskatchewan
• Information provided by (Responsible Party): Phil Chilibeck, University of Saskatchewan

Study Description

Brief Summary:

Forty physically active men and women aged 18-45y will take part in an 8-week resistance training program, randomized (double blind) 1:1 into each of two groups. Twenty participants will be randomized to receive 60 g/d of hemp powder (containing approximately 40 g protein and 9 g oil) supplementation and 20 randomized to receive 60 g/d of soy supplementation (matched to the hemp for macronutrients and calories) during eight weeks of training. Each participant will complete testing before and after the intervention for assessment of body composition (lean tissue, fat, and bone mass), strength, central fatigue, markers of inflammation, and bone resorption. Over the 8-weeks of training, participants will train four-five days per week for 1-1.5 hours per session with exercises targeting all major muscle groups. The training will involve a "two day split" where different muscle groups are trained on two consecutive days (day 1 involves chest, back, and arms; day 2 legs, shoulders, and abdominals). Resistance training will provide the necessary stimulus for protein synthesis to optimize the effect of a protein-containing nutritional supplement. The hemp or soy powder will be consumed in two doses (i.e. 30 g powder containing 20 g protein per dose) immediately after exercise sessions and one hour after exercise. This dosing regimen is optimal for stimulating muscle protein synthesis and building muscle mass . On the one non-training day per week the two doses will be consumed with meals.

Condition or disease	Intervention/treatment	Phase
Sarcopenia	Dietary Supplement: Hemp powder; Dietary Supplement: Soy Powder	Not Applicable

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 34 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Other
• Official Title: The Benefits of Hemp Protein Supplementation During Resistance Training
• Study Start Date: August 2015
• Actual Primary Completion Date: December 2015
• Actual Study Completion Date: December 2015

Arms and Interventions

Arm	Intervention/treatment
Experimental: Hemp powder; Hemp powder supplement	Dietary Supplement: Hemp powder; Hemp powder supplement
Active Comparator: Soy powder; Soy powder supplement	Dietary Supplement: Soy Powder; Soy powder supplement

Outcome Measures

Primary Outcome Measures :

1. Change in lean tissue mass (kg) [ Time Frame: 8 weeks ]
   Lean tissue mass measured with dual energy x-ray absrorptiometry

Secondary Outcome Measures :

1. Change in fat mass (kg) [ Time Frame: 8 weeks ]
   Fat mass as measured by dual energy x-ray absorptiometry
2. Change in bone mass (grams) [ Time Frame: 8 weeks ]
   Bone mass as measured by dual energy x-ray absorptiometry
3. Change in elbow flexor muscle thickness (cm) [ Time Frame: 8 weeks ]
   Muscle thickness as assessed by ultrasound
4. Change in knee extensor muscle thickness (cm) [ Time Frame: 8 weeks ]
   muscle thickness as measured by ultrasound
5. Change in bench press strength (kg) [ Time Frame: 8 weeks ]
   Bench press strength as assess on a plate-loaded machine by the 1-RM method
6. Change in arm curl strength (kg) [ Time Frame: 8 weeks ]
   Arm curl strength as assessed with dumbbells by the 1-RM method
7. Change in leg press strength (kg) [ Time Frame: 8 weeks ]
   Leg press strength as assessed on a leg-press machine by the 1-RM method
8. Change in inflammation by interleukin-6 (mmol/l) levels [ Time Frame: 8 weeks ]
   Interleukin-6 levels measured from saliva samples
9. Change in inflammation by C-reactive protein (mmol/l) levels [ Time Frame: 8 weeks ]
   C-reactive protein levels measured from saliva samples
10. Change in bone resorption (N-telopeptides) (mmol/l) [ Time Frame: 8 weeks ]
    N-telopeptides measured from urine samples
11. Change in voluntary muscle activation (Nm) [ Time Frame: 8 weeks ]
    Voluntary muscle activation as measured by the interpolated twitch technique

Eligibility Criteria

• Ages Eligible for Study: 18 Years to 45 Years (Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Criteria

Inclusion Criteria:

• At least 6 months experience with resistance training

Exclusion Criteria:

• Allergies to hemp or soy
• Consumption of other nutritional supplements in previous month
• Answered "yes" to questions on the Physical Activity Readiness Questionnaire

Contacts and Locations

Locations

Canada, Saskatchewan

University of Saskatchewan

Saskatoon, Saskatchewan, Canada, S7N 5B2

Sponsors and Collaborators

University of Saskatchewan

Investigators

• Principal Investigator: Philip Chilibeck; University of Saskatchewan

More Information

• Responsible Party: Phil Chilibeck, Ph.D., University of Saskatchewan
• ClinicalTrials.gov Identifier: NCT02529917
• Other Study ID Numbers: 15-95
• First Posted: August 20, 2015
• Last Update Posted: May 5, 2017
• Last Verified: May 2017

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: No

Additional relevant MeSH terms:

Sarcopenia; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical