The Born in Guangzhou Cohort Study (BIGCS) (BIGCS)
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The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.
Condition or disease
Intrauterine HyperglycemiaPregnancy OutcomesNeurodevelopmentImmune DevelopmentChildhood ObesityHost and Microbiome
Other: No intervention
Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Pregnant women attending their first routine antenatal examinations (usually around week 16) and their partners and offsrping
Pregnant women with <20 weeks of gestation
Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
201041-E00741 ( Other Grant/Funding Number: Guangzhou Science and Technology Bureau, Guangzhou, China )
2012J5100038 ( Other Grant/Funding Number: Guangzhou Science and Technology Bureau, Guangzhou, China )
201508030037 ( Other Grant/Funding Number: Guangzhou Science and Technology Bureau, Guangzhou, China )