Neural Correlates of Stress Hormones (Cort-fMRI)
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|ClinicalTrials.gov Identifier: NCT02523664|
Recruitment Status : Recruiting
First Posted : August 14, 2015
Last Update Posted : January 31, 2018
|Condition or disease||Intervention/treatment||Phase|
|Borderline Personality Disorder PTSD||Drug: Hydrocortisone Drug: Placebo||Not Applicable|
The investigators have recently shown that hydrocortisone enhances rather than impairs memory retrieval in patients with posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). In contrast, in healthy participants memory retrieval was impaired after hydrocortisone compared to placebo.
The proposed studies aim to further investigate these findings and to understand the underlying neuronal correlates. Thus, the mechanisms of enhanced memory retrieval after hydrocortisone in patients with BPD and PTSD will be investigated by fMRI.
In a placebo-controlled study, the effects of 10mg hydrocortisone on brain activity, in particular the hippocampus, will be investigated in patients with PTSD and BPD and will be compared with those in healthy control participants. During the fMRI session, a declarative memory task (retrieval of a previous learned word list) and an autobiographical memory test will be performed. Effects of hydrocortisone on resting state brain activity and the neuronal correlates of memory retrieval will be analysed.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||75 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Why Does Cortisol Enhance Memory Retrieval in Patients With Borderline Personality Disorder and Posttraumatic Stress Disorder? Investigating the Neuronal Correlates of Cortisol Administration and the Effects of Stress Exposure|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||July 2018|
|Estimated Study Completion Date :||July 2018|
Active Comparator: Hydrocortisone
10 mg hydrocortisone orally
effects of hydrocortisone on memory while fMRI
Placebo Comparator: Placebo
- brain activation after hydrocortisone [ Time Frame: 20 min ]fMRI
- memory retrieval after hydrocortisone [ Time Frame: 10 minutes ]Retrieval of a previous learned word list
- memory retrieval after hydrocortisone [ Time Frame: 20 minutes ]autobiographic memory retrieval
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02523664
|Contact: Katja Wingenfeld, PhD 004930450517534 firstname.lastname@example.org|