Trial record 22 of 158 for:    genetics AND Parkinson's disease

Hereditary Parkinson s Disease Natural History Protocol

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02511015
Recruitment Status : Completed
First Posted : July 29, 2015
Last Update Posted : August 9, 2018
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Heart, Lung, and Blood Institute (NHLBI) )

Brief Summary:


- Parkinson s disease is a disease of the nervous system that affects movement. People usually get it in their 70s or 80s. Early onset Parkinson s disease (EOPD) begins before the age of 50. Researchers think EOPD may be caused by a mutation in a gene. They want to study the genetic causes so they can find therapies for this disease.


- To better understand the genetic causes of EOPD.


  • Adults ages 18 80 with a history of EOPD. Their family members, who do not have Parkinson s disease, can join as controls.
  • Healthy volunteers ages 18 80.


  • Participants with EOPD and their relatives will be screened with a review of medical records. Healthy volunteers will have medical history, physical exam, and blood drawn.
  • Relatives may send blood samples to NIH to test for mutations in genes that are linked to Parkinson s disease. They may have a physical exam.
  • Participants may be asked to return to clinic for another visit that can last up to 2 hours.
  • During this visit, participants will have blood taken from a vein in the arm via a needle stick.
  • Participants may give a sample of their skin. The skin on the arm or leg will be numbed and a small skin punch biopsy will be taken with a special needle.
  • Some cells from the blood or skin sample may be grown in a lab to establish cell lines. The cells may also potentially be genetically modified to make stem cells.
  • Researchers may perform genetic analysis on the samples to compare them to EOPD patient samples.

Condition or disease
Parkinson Disease 6, Early-Onset Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human Parkinson Disease Autosomal Recessive, Early Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Detailed Description:
The majority of subjects with the degenerative Parkinson's Disease (PD) present in the 7th and 8th decades of life. In contrast, this neurologic disease can present within the first 5 decades of life. This early onset presentation is more likely to have a direct genetic cause relative to the etiology of the degenerative form of the disease. Our understanding of the genetic causes of early onset Parkinson's Disease (EOPD) may help us find therapies for both the genetic and degenerative illnesses. Data from our laboratory and others show that genetic mutations associated with EOPD, disrupt cellular stress-response programs. These perturbations, in turn, impair cell-repair process, which is hypothesized to increase susceptibility to dopaminergic neuron degeneration linked to EOPD and degenerative PD. At the same time, patients with EOPD have a variable age of onset (spanning from 8 years to 41 years in the subjects in our cohort) and disease penetrance (severity of symptoms). The hypothesis we propose to test is whether the number and allele distributions of EOPD susceptibility gene mutations account for the variable age of onset and disease penetrance. This hypothesis will be tested in this natural history protocol by genotyping subjects with EOPD to define their genetic defects and to explore the cellular reparative function in these individuals using peripheral blood cells, skin biopsy derived fibroblasts and induced pluripotential stems cells derived from these subjects. In parallel, the phenotype of these subjects will be evaluated by the NINDS Parkinson's Clinic. Together, these data should advance our insight into the genotype-phenotype in EOPD pathophysiology.

Study Type : Observational
Actual Enrollment : 31 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Hereditary Parkinson's Disease Natural History Protocol
Study Start Date : July 28, 2015
Actual Primary Completion Date : August 15, 2017
Actual Study Completion Date : August 15, 2017

Primary Outcome Measures :
  1. The primary objective of this study is to genetically define the combination of autosomal recessive genetic defects linked to EOPD and characterize their composite molecular and physiologic effect on cellular homeostasis and response to dopamine... [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. The secondary objective is to evaluate whether these composite of these genetic defects and their effects on cellular quality control correlate to age of onset and disease penetrance in EOPD subjects. [ Time Frame: 5 years ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Parkinson's Subjects

- Age 18 years to 80 years old with a history of early onset Parkinson's disease or Parkinsonism (Presentation within the first five decades of life).

Healthy Control Subjects

- Age 18 years to 80 years old with no history or family history of Parkinson's disease or Parkinsonism.

Family Member Control Subjects

Family members, of enrolled EOPD subjects, who themselves do not have

- Parkinson's disease or Parkinsonism can be enrolled as controls on this study.

All Subjects

  • Willingness and legal ability to give and sign informed study consent
  • Willingness to have blood or tissue samples studied, and potentially stored for future research


All Subjects

  • Subjects who are unable or unwilling to sign an informed consent
  • Subjects with genetic defects associated with diseases including other neurologic syndromes.
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02511015

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Derek P Narendra, M.D. National Institute of Neurological Disorders and Stroke (NINDS)

Additional Information:
Responsible Party: National Heart, Lung, and Blood Institute (NHLBI) Identifier: NCT02511015     History of Changes
Other Study ID Numbers: 150155
First Posted: July 29, 2015    Key Record Dates
Last Update Posted: August 9, 2018
Last Verified: March 14, 2018

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Heart, Lung, and Blood Institute (NHLBI) ):
Early Onset Parkinson's Disease
Cellular Quality Control Programs

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases