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Acute Effects of Fats on Satiety and Energy Needs

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ClinicalTrials.gov Identifier: NCT02496936
Recruitment Status : Recruiting
First Posted : July 14, 2015
Last Update Posted : October 25, 2018
Sponsor:
Information provided by (Responsible Party):
Matthew Picklo, USDA Grand Forks Human Nutrition Research Center

Brief Summary:
The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Condition or disease Intervention/treatment Phase
Obesity Other: SFA Other: MUFA Other: PUFA-LA Other: ALA Other: LCn3 Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 23 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Other
Official Title: Acute Effects of Fats on Satiety and Energy Needs
Actual Study Start Date : December 2015
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Arm Intervention/treatment
Experimental: Saturated Fat/SFA
30 grams saturated fat in the form of heavy whipping cream will be provided to subject in a smoothie drink
Other: SFA
High saturated fatty acid/SFA oil source

Experimental: Monounsaturated Fat/MUFA
30 grams monounsaturated fat in the form of high oleic canola oil will be provided to subject in a smoothie drink
Other: MUFA
High monounsaturated fatty acid/MUFA oil source

Experimental: Polyunsaturated Fat Linoleic/PUFA-LA
30 grams polyunsaturated fat in the form of high linoleic sunflower oil will be provided to subject in a smoothie drink
Other: PUFA-LA
High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

Experimental: Polyunsaturated Fat Alpha-Linolenic/ALA
30 grams polyunsaturated fat in the form of flaxseed oil will be provided to subject in a smoothie drink
Other: ALA
High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source

Experimental: Polyunsaturated Fat Omega-3/LCn3
30 grams polyunsaturated fat in the form of fish oil (Coromega Omega3 Squeeze) will be provided to subject in a smoothie drink
Other: LCn3
High polyunsaturated fatty acid (omega-3)/LCn3 oil source




Primary Outcome Measures :
  1. Acute effect of fat intake on energy expenditure as determined by metabolic rate [ Time Frame: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours ]


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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • body mass index between 18.0-34.9 kg/m2
  • free of major diagnosed, untreated medical conditions
  • controlled hypertension
  • non-smoking or use of other tobacco products, including e-cigarettes
  • not taking steroid-based medications
  • not planning to or currently attempting to gain or lose weight
  • willing to comply with study demands
  • use of oral contraceptives
  • low intake of long chain omega 3 fatty acids

Exclusion Criteria:

  • diagnosed eating disorders
  • diabetes (blood sugar ≥ 126 mg/dl)
  • hypertension (systolic ≥ 160 mmHg or diastolic > 100 mmHg)
  • diagnosed cardiovascular, pulmonary, skeletal and metabolic disease
  • currently pregnant or planning to become pregnant, or lactating
  • taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02496936


Contacts
Contact: Matthew Picklo, PhD 701-795-8380 matthew.picklo@ars.usda.gov
Contact: Bret Rust, PhD 701-795-8139 bret.rust@ars.usda.gov

Locations
United States, North Dakota
USDA Grand Forks Human Nutrition Research Center Recruiting
Grand Forks, North Dakota, United States, 58203
Contact: Angela Scheett, MPH, RD    701-795-8386    angela.scheett@ars.usda.gov   
Sponsors and Collaborators
USDA Grand Forks Human Nutrition Research Center
Investigators
Principal Investigator: Matthew Picklo, PhD USDA Grand Forks Human Nutrition Research Center

Responsible Party: Matthew Picklo, PhD, USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier: NCT02496936     History of Changes
Other Study ID Numbers: GFHNRC508
First Posted: July 14, 2015    Key Record Dates
Last Update Posted: October 25, 2018
Last Verified: October 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Matthew Picklo, USDA Grand Forks Human Nutrition Research Center:
Energy Expenditure
Appetite
Satiety