The Impact of the SCN9A Gene Polymorphism on Postoperative Pain
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The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.
Condition or disease
Procedure: cesarean sectionDrug: Opioid Tramadol
SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.
The pain will be evaluated with the visual analog scale
Secondary Outcome Measures :
Opioid consumption [ Time Frame: Up to postoperative 24 hours ]
The total amount of the tramadol administered to the patient will be recorded
Biospecimen Retention: Samples With DNA
Two ml blood will be collected from the peripheral venous before the operation and all blood samples will be stored at -80℃. Genomic DNA will be extracted from the blood samples and polymorphism in SCN9A gene will be identified by PCR
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The women in 36 to 40 weeks of pregnancy undergoing cesarean section will be included
The women aged 18 to 45,
in 36 to 40 weeks of pregnancy
undergoing cesarean section
History of chronic pain or pain disorders
Severe cardiovascular, kidney or liver diseases
Alcohol or drug abuse
Unable to use the Patient controlled analgesia (PCA) pump